Neurology
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A Review of Updated Guidelines Regarding Bradycardia and Cardiac Conduction Delay
The American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society have established updated guidelines on the evaluation and management of patients with bradycardia and conduction delays. Many key elements remain largely unchanged from prior guideline recommendations on pacemakers published in 2008 and 2012, but there are important new definitions, recommendations, and areas of emphasis.
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Clinical Outcomes After Oral Anticoagulant-Associated Intracerebral Hematoma
In this meta-analysis of multiple observational studies, clinical outcomes after oral anticoagulant-associated intracerebral hematoma were similar for those associated with vitamin K antagonists or the new class of direct oral anticoagulants.
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Correlation of Electromyography With Pathology in Myopathy
A detailed analysis of electromyography features showed a high correlation with muscle pathology. However, pathologic changes on muscle biopsy may be present even with a totally normal electromyogram.
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Apolipoprotein E and CSF Levels in Men and Women With Alzheimer’s Disease
Apolipoprotein E epsilon 4 (APOE4) genotype, the stronger genetic risk factor for late-onset Alzheimer’s disease, negatively affects cerebrospinal levels of tau protein in a sex-dependent manner, whereby the effect of APOE4 is stronger in women than men.
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Utility of Ictal Magnetoencephalography for Identifying Seizure Onset Zone
In a review of 377 magnetoencephalography (MEG) studies in epilepsy patients undergoing presurgical workup, 44 patients were found to have one or more seizures during routine recordings, lasting up to a mean of 51.2 minutes. Ictal MEG provided unique localizing data in about one-third of patients. For patients with frequent seizures or reliably induced seizures, MEG may be a useful supplemental tool for medically refractory epilepsy patients undergoing presurgical evaluation.
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Effect of Sleep on Levodopa-Induced Dyskinesia in Parkinson’s Disease
Parkinson’s disease is associated with sleep disorders commonly. Disrupted sleep patterns appear to make dyskinesias worse in patients treated with levodopa therapy.
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Omadacycline Injection and Tablets (Nuzyra)
The FDA has approved a broad-spectrum antibiotic for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections.
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Nocturia: Does Salt Intake Play a Role?
Researchers suggest that excessive salt intake can contribute to urinary frequency and nocturia.
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Exercise Improves Physical Function in Patients With Knee Osteoarthritis
Tailored exercise therapy can improve physical functioning in patients with knee osteoarthritis and comorbid conditions.
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Limited English Proficiency Associated With Significant Differences in End-of-Life Care
In a retrospective cohort study, patients with limited English proficiency had lower rates of do not resuscitate orders, comfort measures orders, and advance directives; higher rates of receiving certain types of life support; and longer hospital stays compared to their English-speaking counterparts.