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Natalizumab is a monoclonal antibody that is FDA-approved for the treatment of relapsing-remitting multiple sclerosis (MS). Among the available options to treat MS, it is one of the most effective.
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In a Phase 2 trial, antibodies to calcitonin gene-related peptide resulted in a significant decrease in migraine days measured from baseline to weeks 5 to 8 after one intravenous infusion of the medication, as compared to a placebo infusion. But the high-rate of placebo response (50%) warrants caution in the interpretation of the study results and requires more investigation.
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Ventilator-associated pneumonia (VAP) is a serious complication for intubated patients. It causes significant morbidity and mortality, increases healthcare costs and is the main reason for antibiotic use in the intensive care unit (ICU).
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Asymptomatic carriage of C. difficile in adult hospitalized patients varies regionally, but estimates suggest that 4% to 23% of patients being admitted to hospital in the U.S. may be colonized with toxogenic strains of C. difficile (TCD).
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147 patients on stable antiretroviral therapy (ART) were randomized to receiving rosuvustatin 10 mg daily or placebo. After 24 weeks rosovustatin both reduced cystatin C and slowed kidney function decline as assessed by a serum creatinine-based equation.
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FDA approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) caused by susceptible gram-positive organisms including Staphylococcus aureus (MRSA and MSSA), Streptococcus agalactiae, Streptococcus anginosus group, Streptococcus pyogenes, and Enterococcus faecalis.
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A 46-year-old man was admitted to our hospital due to progressive dyspnea, non-productive cough and fever. Two months prior to admission, he started to develop sustained weight loss and dyspnea associated with exertion. Ten-days prior to his presentation, dyspnea progressed to minimal exertion significantly limiting his functional status.
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Using retrospective cohort data from a national survey of medical and mixed medical-surgical ICUs, this study found that nurse practitioner (NP)/physician assistant (PA) staffing was common and not associated with any differences in in-hospital mortality compared to ICUs without NP/PAs.
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Dehydration is an independent predictor of discharge outcome and admission cost in acute ischaemic stroke.
