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Bacterial resistance to antibiotic treatment has concerned the medical community since the introduction of the first antibiotics in the 1920s. Development of new anti-infective agents has been precipitated by increasing resistance to older agents and classes of agents. While high rates of resistant organisms have been particularly problematic in hospital intensive care units, serious resistance now is being encountered in community-acquired infections. This review will focus on the clinical aspects of antibiotic resistance in community-acquired respiratory infections, pharyngitis, skin infections, and urinary tract infections.
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There is a role for endovascular therapy, such as stenting, as reported in Stroke, in the setting of failed medical management with anticoagulants.
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The probability of in-hospital death was higher for patients with the lowest total FOUR score than for those with the lowest total GCS score.
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In a randomized trial comparing immediate radiation therapy to delayed treatment in patients who underwent primary surgical resection of low-grade gliomas, overall survival was not significantly different between the 2 groups.
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Whole body fluorodeoxyglucose positron emission tomography scanning helps uncover the associated tumor, and recently proposed criteria may assist in the diagnosis. In many instances, prompt treatment of the tumor and immunotherapy result in symptom stabilization or neurologic improvement.
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In a consecutive case series of 18 patients with severe essential tremor who underwent implantation of bilateral thalamic DBS electrodes, high-frequency stimulation resulted in significant, long-term improvement in their quality of life.
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Although the tau negative and positive histologies are predicted to some extent by the clinical onset, the extent of the overlap and the convergence of the syndromes in the course of the disease argue in favor of maintaining the clinical and pathological varieties under a single umbrella.
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Long-term vasodilator therapy with either nifedipine or enalapril changed neither the hemodynamic burden of severe aortic regurgitation nor reduce or delay the need for valve replacement surgery in asymptomatic patients with chronic severe aortic regurgitation and normal LV function.
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Volume outcome data for percutaneous coronary interventions (PCI) was largely collected and reported in the balloon angioplasty era. Thus, this report from New York state's PCI reporting system from 1998 to 2000 is of interest. This database of over 100,000 cases, which can be adjusted for severity of illness, was interrogated for 3 outcomes: in-hospital mortality, same-day coronary artery bypass surgery (CABG), and same-stay CABG.
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An early invasive strategy did not result in an expected differential in the primary end point.
