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In a case-control study using a biomarker for lignan intake, women with breast cancer who had higher levels of the biomarker post-diagnosis had a reduced risk of mortality over a median follow-up period of 6 years compared to women with low levels of the biomarker.
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Data from this large observational trial with an average follow-up of over 8 years suggest that even 15 minutes a day of moderate-intensity exercise, such as taking a brisk walk, provides significant health benefits in terms of lowered mortality risks and life extension.
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Participation in Weight Watchers resulted in a greater weight loss over a year than did clinical intervention in a primary care office.
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This is the second in a three-part series about the design and conduct of clinical research.
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In postmenopausal women, constipation is associated with having major risk factors for cardiovascular disease and increased cardiovascular risk.
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This basic science paper explores the role of the tumor microenvironment in the development of tumor resistance to chemotherapy. Two distinct fatty acid molecules, endogenously produced by cancer cells in response to platinum-based chemotherapy drugs, were found to confer significant tumor chemoresistance. Remarkably, these two fatty acids also were shown to be present in several commercial fish oil products, and, of potential import to clinicians, the oral administration of small amounts of these fish oils induced tumor resistance to cisplatin in a mouse tumor model.
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Most patients with ST-elevation myocardial infarction (STEMI) present to hospitals that are not capable of percutaneous coronary intervention (PCI). Rapid transfer to PCI-capable facilities for primary PCI may result in earlier reperfusion of the infarct artery and better clinical outcomes. However, delays in transfer may diminish the mortality benefit achieved with primary PCI in STEMI.
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Anatomic definition of coronary artery lesions by invasive coronary angiography (ICA) or computed tomography coronary angiography (CCTA) has limitations.
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