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In a randomized, double-blind, placebo-controlled trial, clonidine and venlafaxine both proved superior to placebo in reducing hot flashes in breast cancer patients. The study was insufficiently powered to prove superiority of one drug over the other. However, venlafaxine produced earlier reductions and it appeared clonidine had more sustained effect (i.e., at 12 weeks of treatment).
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Tadalafil, Eli Lillyâs blockbuster drug for erectile dysfunction, has now been approved to treat signs and symptoms of benign prostatic hyperplasia. Tadalafil is the first drug of its class to be approved for this indication.
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From a large cohort of women followed prospectively and with an adjunct meta-analysis of existing evaluable studies, a clearly demonstrated, nearly universal (i.e., across tumor types) incremental increase in cancer incidence was observed with advancing height.
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A newly developed instrument to measure brief physical activity counseling in primary care demonstrates that physicians need to do a better job.
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Recent retrospective studies in Europe have created concern because of an observed increased risk of cancer (hazard ratio = 1.55) in users of insulin glargine (GLAR) compared to nonusers.
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The authors conclude that patients with coronary stents undergoing an invasive procedure are at high risk of perioperative cardiovascular and bleeding complications, and that these are associated with a high mortality.
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Since there is a lack of prospective data on the frequency of which constrictive pericarditis (CP) develops after acute pericarditis (AP), this group of investigators from Torino, Italy, conducted such a study.
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Saddle pulmonary embolism was found in 37 of 680 patients with documented pulmonary embolism (PE) in this community hospital study. The great majority of these patients did well on standard therapy without thrombolytics, emphasizing that the radiographic finding of saddle PE should not by itself be equated with the much more serious clinical entity of massive PE.
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