Browse Internal Medicine Articles by Topic

Metformin and Colorectal Cancer Risk

In a retrospective cohort study of patients with type 2 diabetes who had ≥ 1 adenoma detected at baseline colonoscopy and a repeat colonoscopy 1-10 years later, metformin use lowered the risk of subsequent adenomas after polypectomy.

Cardiovascular Events Associated with Masked Hypertension and White-coat Hypertension

Analysis from the Dallas Heart Study consisting of 3027 adults revealed that both white-coat hypertension and masked hypertension were independently associated with increased cardiovascular events, and, therefore, home blood pressure monitoring is recommended for U.S. adults, whether symptomatic or asymptomatic.

ECG Review: Early Repolarization or Something More?

Clinical Briefs

In this section: potential good cardiovascular news; spironolactone best add-on for resistant hypertension; and questions about Vitamin D for primary care practice.

Mepolizumab Injection (Nucala)

Mepolizumab is indicated for add-on maintenance treatment of adult patients ≥ 12 years of age with severe asthma and with an eosinophilic phenotype.

Carotid Occlusion Rarely Develops from Asymptomatic Carotid Artery Stenosis

Recent study indicates that the risk of progression to carotid occlusion is well below the risk of carotid stenting or carotid endarterectomy.

Utility of Non-traditional Risk Factors in Patients Ineligible for Statin Therapy

Adding additional risk factors not in the pooled risk equation to low-risk subjects identified a sub-group with an observed event rate > 7.5% who may warrant statin therapy.

Effect of Modified Valsalva Maneuver for Emergency Treatment of Supraventricular Tachycardia

In patients presenting with supraventricular tachycardia, a modified Valsalva maneuver with leg elevation and supine positioning at the end of strain was demonstrated to be more effective than the standard Valsalva maneuver at restoring normal sinus rhythm.

Ceftazidime-avibactam — Formulary Considerations

Ceftazidime-avibactam is a new beta-lactam/beta-lactamase inhibitor combination approved for the treatment of complicated intra-abdominal infections in combination with metronidazole, and complicated urinary tract infections, including pyelonephritis in patients with limited alternative treatment options.

Idarucizumab Injection (Praxbind)

The FDA has approved the first reversal agent for a direct oral anticoagulant. Idarucizumab is a humanized monoclonal antibody fragment derived from an IgG1 isotype molecule.