Internal Medicine
RSSArticles
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New Insights Into Alveolar Mechanics and Gas Exchange in Experimental Acute Respiratory Distress Syndrome
Experimental acute respiratory distress syndrome was induced in mice to study local alveolar gas dynamics using advanced microimaging techniques. Heretofore unrecognized disturbances in alveolar ventilation will alter our understanding of alveolar mechanics and gas exchange dysfunction as well as promote the use of recruitment maneuvers.
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Swallowing Dysfunction in Critical Illness
Maintaining a high index of suspicion for the presence of possible swallowing dysfunction is key for the clinician.
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Clinical Briefs
In this section: another reason to take vitamin D supplements; polishing physical exam skills; and comparing the relationship between uric acid, fructose, and hypertension.
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Elbasvir and Grazoprevir Tablets (Zepatier)
The FDA has approved another oral interferon-free regimen for the treatment of chronic hepatitis C (HCV) genotypes 1 and 4.
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Should Postmenopausal Women Be Encouraged to Take Calcium?
A systematic review of randomized, controlled trials of calcium supplementation found only small non-progressive increases in bone mineral density. This supports the clinical conclusion that supplementation alone is insufficient to prevent fracture risk.
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Association of Coffee Consumption with Total and Cause-specific Mortality
Regular consumption of both caffeinated and decaffeinated coffee were found to be inversely associated with risk of total mortality and mortality attributed to cardiovascular disease and neurologic diseases.
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High Blood Pressure: How Low Should We Go? SPRINT and a New Meta-analysis
A recent meta-analysis supports the benefit of targeting lower blood pressure levels.
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ECG Review: What Has Happened in 8 Minutes?
The ECG in the figure illustrates how rapidly ST-T wave changes may develop during active stages of acute ST elevation myocardial infarction. In this case, no more than 8 minutes was necessary for the ECG to evolve from a minimally abnormal tracing to the dramatic picture of diffuse ST-T wave changes.
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Clinical Briefs
In this section: The measurement of C-reactive protein in hidradenitis patients may enhance assessment of disease severity; studying the relationship between gut flora and mood disorders; and weighing the benefits of administration of pre-exposure prophylaxis immediately before and after sexual activity.
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Lesinurad Tablets (Zurampic)
Lesinurad is a drug with a different mechanism of action to augment the action of a xanthine oxidase inhibitor, resulting in additional reduction of serum uric acid levels.