Internal Medicine
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A New Risk Score for Stroke in Atrial Fibrillation
SYNOPSIS: A new, simpler score for stroke risk prediction in atrial fibrillation patients uses biomarkers to supplant many clinical variables and outperforms the CHA2DS2-VASc score in two large cohorts.
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Antibiotic Treatment in Community-acquired Pneumonia
SYNOPSIS: In patients with newly diagnosed community-acquired pneumonia, basing the duration of antibiotic treatment on clinical stability criteria led to a significant reduction in duration of antibiotic treatment without an increased risk of adverse outcomes.
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Discharge Antibiotic Prescriptions Often Are Inappropriate with Regard to Choice, Dose, Duration
SYNOPSIS: Seventy percent of discharge antibiotic prescriptions are inappropriate.
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High-sensitivity Cardiac Troponin
In a recent trial, the use of high-sensitivity troponin T did not increase the use of coronary angiography or stress testing, but did reduce ED length of stay and costs.
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Hemoconcentration Associated with Lower Mortality in Acute Heart Failure
Among patients hospitalized for acute heart failure, hemoconcentration was associated with reduced 90-day mortality and may be a useful marker for guiding therapy.
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Mechanical Circulatory Support in Cardiogenic Shock: Can Any Device Move the Mortality Needle?
In a small randomized trial of patients with cardiogenic shock secondary to acute myocardial infarction, the Impella heart pump failed to improve mortality compared with intra-aortic balloon counterpulsation.
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ECG Screening of Athletes
T-wave inversion confined to ECG leads V1-V2 is a normal variant, but T-wave inversion beyond V2 is rare and may warrant further investigation.
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Weight Loss to Make You Feel Better, Live Longer, and Lower Your Risk of Atrial Fibrillation
Significant and sustained weight loss through bariatric surgery reduced the risk of developing new-onset atrial fibrillation in a Swedish cohort of obese individuals.
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Hyperoxia in ICU Patients May Cause Harm
Patients randomized to maintain oxygen saturation between 94-98% experienced better outcomes than patients allowed to receive partial pressure of oxygen > 150 mmHg.
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Surviving Critical Illness: Who Returns to Work?
Three months after surviving critical illness due to respiratory failure or shock, more than 60% of survivors experienced a decrease in employment. At 12 months, almost half of survivors still experienced a decrease in employment.