Internal Medicine
RSSArticles
-
Targeting Fyn Kinase in Alzheimer’s Disease: Another Failed Clinical Trial
In this multicenter Phase IIa clinical trial in mild Alzheimer’s disease dementia, the tyrosine kinase Fyn inhibitor AZD0540 had no significant effects after 52 weeks of treatment.
-
Calcitonin Gene-Related Peptide Targeting Therapies for Migraine
Two randomized clinical trials showed that calcitonin gene-related peptide targeting therapies are effective and safe for primary headache disorders.
-
Antisense Oligonucleotide Treatment of Huntington’s Disease: A Novel Potential Treatment
In this Phase I/IIa clinical trial, investigators administered antisense huntingtin oligonucleotides intrathecally to patients with early Huntington’s disease (HD), and demonstrated safety, tolerability, and dose-dependent reduction in CSF mutant huntingtin. This approach now is being tested for clinical efficacy in HD in a Phase III clinical trial.
-
Is There Group Beating?
How should one proceed in analyzing this challenging rhythm strip?
-
Dupilumab Injection (Dupixent)
This is the first FDA-approved treatment for chronic rhinosinusitis with nasal polyposis.
-
Mechanism of Persistence of Moraxella catarrhalis in Patients With COPD
Investigators examined the mechanism that allows Moraxella catarrhalis to persist in some patients with COPD.
-
Early vs. Delayed Cardioversion: A Nonshocking Result
For patients presenting to an ED with recent-onset atrial fibrillation, using rate control and outpatient cardioversion only as needed was associated with a high rate of spontaneous conversion within 48 hours of arrhythmia onset and noninferior short-term outcomes compared to immediate cardioversion in the ED.
-
Mind-Body Techniques May Enhance Cognitive Fitness in Older Adults
A meta-analysis regarding mind-body techniques and cognitive fitness in older adults points to enhanced cognitive performance associated with mind-body interventions in older patients, especially those without preexisting cognitive decline.
-
Help Us Help You
-
Behavioral Interventions for Menopausal-Related Insomnia Improve Depression
In a randomized, controlled trial comparing the behavioral interventions cognitive behavioral therapy for insomnia (CBTI) and sleep reduction therapy (SRT) to a control intervention of sleep hygiene education, investigators found CBTI and SRT therapy improved insomnia and depressive symptoms in postmenopausal women with menopausal-related insomnia.