Internal Medicine
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Antisense Oligonucleotide Treatment of Huntington’s Disease: A Novel Potential Treatment
In this Phase I/IIa clinical trial, investigators administered antisense huntingtin oligonucleotides intrathecally to patients with early Huntington’s disease (HD), and demonstrated safety, tolerability, and dose-dependent reduction in CSF mutant huntingtin. This approach now is being tested for clinical efficacy in HD in a Phase III clinical trial.
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Is There Group Beating?
How should one proceed in analyzing this challenging rhythm strip?
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Dupilumab Injection (Dupixent)
This is the first FDA-approved treatment for chronic rhinosinusitis with nasal polyposis.
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Mechanism of Persistence of Moraxella catarrhalis in Patients With COPD
Investigators examined the mechanism that allows Moraxella catarrhalis to persist in some patients with COPD.
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Early vs. Delayed Cardioversion: A Nonshocking Result
For patients presenting to an ED with recent-onset atrial fibrillation, using rate control and outpatient cardioversion only as needed was associated with a high rate of spontaneous conversion within 48 hours of arrhythmia onset and noninferior short-term outcomes compared to immediate cardioversion in the ED.
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Mind-Body Techniques May Enhance Cognitive Fitness in Older Adults
A meta-analysis regarding mind-body techniques and cognitive fitness in older adults points to enhanced cognitive performance associated with mind-body interventions in older patients, especially those without preexisting cognitive decline.
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Behavioral Interventions for Menopausal-Related Insomnia Improve Depression
In a randomized, controlled trial comparing the behavioral interventions cognitive behavioral therapy for insomnia (CBTI) and sleep reduction therapy (SRT) to a control intervention of sleep hygiene education, investigators found CBTI and SRT therapy improved insomnia and depressive symptoms in postmenopausal women with menopausal-related insomnia.
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Hot Beverages and Esophageal Cancer
In a cohort of more than 50,000 people, there was an increased risk of esophageal squamous cell carcinoma in those who consumed higher quantities of mostly black tea at higher temperatures.
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Digital Applications Used in Mental Health Treatment: Two Randomized Studies
Researchers found an improvement in socialization in children with autism and a decrease in acrophobic (fear of heights) symptoms in adults in two distinct studies using different forms of virtual reality and digital applications.