Internal Medicine
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Tenecteplase vs. Alteplase for Thrombolysis in Basilar Artery Occlusion
Basilar artery occlusion is a dangerous clinical syndrome of large artery occlusion that carries a high morbidity and mortality with severe disability in survivors. In multiple trials, alteplase has shown minimal benefit in achieving reperfusion in patients with large artery occlusion, including the basilar artery. Tenecteplase is a modified variant of alteplase that has greater specificity in binding to fibrin, a longer half-life, and can be administered in a single bolus.
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Brain Cancer and Brain Injury Drive Systemic Immunosuppression
Glioblastoma-associated immunosuppression is a significant factor associated with poor survival in this disease. Accumulating evidence suggests that mouse models of glioblastoma and other brain cancers induce systemic immunosuppression through dysregulation of a newly recognized brain-thymus axis and that targeting this pathway may promote more effective immune surveillance of these tumors.
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Polyradiculoneuropathy from Immune Checkpoint Inhibitors
Immune checkpoint inhibitors have become an important part of the armamentarium for the medical treatment of cancers such as melanoma and lung carcinomas. A number of immune-mediated neurological complications have been identified during the use of these agents, including polyradiculoneuropathy.
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Cognitive Deficits in Patients Recovering from COVID-19
Hospitalized COVID-19 patients with cognitive complaints demonstrate reduced attention and executive dysfunction on formal cognitive testing consistent with the same frequency and pattern of cognitive changes associated with critical illness.
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Phospho-Tau217 Blood Biomarker May Help to Diagnose Early Alzheimer’s Disease
Serum phospho-tau217, a biomarker of tau protein that can be detected in the blood, is increased in preclinical Alzheimer’s disease and may have clinical utility for the early detection of brain pathology.
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AstraZeneca Reports 79% Efficacy for U.S. COVID-19 Vaccine Candidate
But NIH raises questions the about data.
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Religion and Spirituality in Primary Care
Religious commitment is intrinsically connected to cultural, mental, spiritual, and societal aspects of wellness, and, thus, should be better recognized by the medical community, whose goal is to provide culturally competent, relationship-centered healthcare. As physicians strive to provide care that is culturally competent and patient-centered, they must be careful to take into account their patients’ deepest human commitments.
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Plant-Based Diet Could Cut Stroke Risk
Eating a diet rich in beans, vegetables, and whole grains was beneficial in a long-term study.
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Modest Improvements in Mortality Rate Disparities in Rural Areas
Black adults living in rural areas in the United States still are more likely to die from diabetes, high blood pressure compared to white adults.
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What Causes Stroke in Young Patients?
A patient might be young, but he or she could be living with serious, unaddressed medical conditions that can lead to disaster.