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The presence of any observed hostility at baseline was associated with a two-fold increased risk of incident ischemic heart disease over a 10-year period of observation.
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In a large community-based cohort of older women, those who self-reported use of multivitamins, vitamin B6, folate, iron, magnesium, zinc, and copper were more likely to die than those who do not. Calcium use, however, was associated with reduced risk.
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In a large randomized trial of healthy men, dietary supplementation with vitamin E (400 IU/day) significantly increased the risk of prostate cancer.
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The FDA has approved the first fixed-dose combination product for the treatment of type 2 diabetes and hypercholesterolemia. This tablet combines a dipeptidyl peptidase-4 inhibitor (sitagliptin) and a HMG-CoA reductase inhibitor (simvastatin).
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The oral administration of 500,000 IU cholecalciferol in fall or winter resulted in a slightly higher risk of falls and fractures vs placebo in 2,256 community-dwelling women aged 70 and above.
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Death by suicide is a significant occupational hazard for physicians. This is strongly associated with professional burnout, which is characterized by a loss of emotional, mental, and physical energy due to continued job-related stress. Studies have identified three factors that are independently associated with burnout for both surgeons and internal medicine physicians hours worked per week, experiencing a work/home conflict within the last three weeks, and how the most recent work/home conflict was resolved.
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It would be fair to say that nearly all formal clinical research begins before it is even recognized as such. Observant clinicians note patterns, or what appear to be patterns, in those they treat.
