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A prospective, multi-center, double-blind, placebo-controlled, randomized trial of daily trimethoprim-sulfamethoxazole (TMP-SMZ; 2 mg TMP and 10 mg SMZ per kg) vs. placebo was conducted in four centers in Australia during 1998-2007 among children birth to 18 years of age with a history of at least one symptomatic, culture-proven urinary tract infection.
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A prospective, multi-center, double-blind, placebo-controlled, randomized clinical trial was conducted of oral supplementation of bovine lactoferrin (BLF) alone or in combination with the probiotic Lactobacillus rhamnosus GG (LGG) to reduce the incidence of late onset sepsis (> 72 hours after birth) in very low birth-weight (VLBW) (< 1,500 g) newborns.
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From June to November 2007, 10 neonates were hospitalized at Chicago's Northwestern University Children's Memorial Hospital.
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In this randomized, double-blind, placebo-controlled trial, 140 patients with uncomplicated falciparum malaria were randomized to rosiglitazone 4 mg BID for four days vs. placebo, in addition to atovaquone/proguanil.
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The diagnosis of C. difficile-related disease (CDD) in children is controversial, as recently reviewed.
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Well-characterized strains of Staphylococcus aureus were grown in broth culture and after lysis PCR primers amplifying the lukS-PV and lukF-PV genes were employed. The amplicon was inserted into a pGEX vector and was transfected into E. coli.
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Data showing an increased risk of MRSA and C. difficile colonization on the footpads and coats of dogs and cats used for pet therapy in hospitals was discussed briefly in May 2009.
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It has been known for years that patients with chronic fatigue syndrome (CFS) have a defect in a major antiviral pathway, the 2-5A/RNase L pathway. The RNaseL produces non-specific viral cleavage and, thus, protects us from many viral infections (innate immunity).
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In this issue: Depression and pregnancy, new vaccine recommendations from the CDC, cortico-steroids and/or antivirals for Bell's palsy, rasagiline and Parkinson's disease, and FDA Actions.
