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In this Phase 2 trial, 105 older patients with acute myeloid leukemia who were either treatment-naïve or at first relapse were treated with one of three schedules of oral sapacitabine: 200 mg twice daily for 7 days (group A), 300 mg twice daily for 7 days (group B), or 400 mg twice daily for 3 days each week for 2 weeks (group C).
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Denosumab is more effective than zoledronic acid at preventing pain in women with advanced breast cancer and bone metastases.
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In a six-site Italian retrospective analysis, treatment of elderly patients with metastatic renal cell carcinoma with sunitinib was shown to be effective but associated with significant toxicity. Although only applied to a subset, pretreatment comprehensive geriatric assessment did not offer predictive value with regard to severe toxicity or efficacy.
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Early pivotal trials demonstrating the efficacy of sorafenib for patients with advanced hepatocellular cancer included primarily those with minimal liver dysfunction (Child-Pugh [CP] class A).
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LAP2 was a randomized, Phase 3 trial to evaluate and compare the modality of surgical staging (laparoscopy vs laparotomy) in endometrial cancer.
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Nutritional support is an essential component of caring for critically ill patients.
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This study conducted in five ICUs at two academic hospitals in San Francisco sought to describe how comfort care is presented to surrogates and if physicians beliefs on whether life support should be withdrawn are associated with the option of comfort care being presented.
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Fagan and colleagues at Denver Health Medical Center examined electronic data collected on all adult patients who generated a medical surgical acute-care room charge during a recent 6-month period and remained on the ward for at least 24 hours.
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