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In SOD1(G93A) transgenic mice, a model for familial ALS, intraspinal injection of a lentiviral vector that produces RNAi-mediated silencing of SOD1 substantially retards both the onset and the progression rate of the disease.
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IgG from all narcolepsy patients significantly enhanced bladder contractile responses to the muscarinic agonist carbachol and to neuronally released acetylcholine compared with control IgG (P < 0.0001), whereas contraction of the sympathetically innervated vas deferens was unaltered.
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SNRIs may be performed safely with only minor side effects to be expected
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Once-daily rasagiline reduces mean daily off-time and improves symptoms of Parkinsons disease in levodopa-treated patients with motor fluctuations, an effect similar to that of entacapone.
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The therapeutic response to indomethacin is the most reliable differential diagnostic criterion for PH vs CH.
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In 15%, and without correlation to maternal disease severity or antibody level, neonatal MG due to the transplacental transfer of maternal antibodies results in transient weakness of the newborn that resolves within 12 weeks.
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The FDA has asked Pfizer to withdraw valdecoxib (Bextra) from the market due to safety concerns.
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The FDA has asked Pfizer to withdraw valdecoxib (Bextra) from the market due to safety concerns.
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