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Rosen and colleagues reported the results of a 1-year, multicenter, randomized, clinical trial comparing the once-a-week administration of alendronate and risedronate to postmenopausal women with osteoporosis (the FACT study-Fosamax Actonel Comparison Trial). The 1053 women were treated with either 70 mg alendronate or 35 mg risedronate weekly, taken with a full glass of water after fasting, and in the upright position after awakening in the morning.
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The well-known mantra of primary ovarian cancer management is surgery. The procedure has modified little in the last 30 years as the goal in advanced cases has been cytoreduction and, in seemingly early cases, it has been accurate staging.
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Stopping Aspirin Before Surgery; The Sponge Returns; Preventing Metabolic Syndrome; FDA Actions
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Odvina and colleagues report 9 patients (8 women and 1 man) who sustained spontaneous, atraumatic, nonspinal fractures while on alendronate treatment. One patient also had a lumbar spinal fracture, but almost all of the fractures occurred in skeletal sites rich in cortical bone. In addition, 6 of the 9 patients displayed either delayed or absent fracture healing.
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Blumenthal and colleagues point out in the introduction that psychological factors are recognized to play a significant and independent role in the development of ischemic heart disease and its complications, but it is not clear if psychological or behavioral interventions will reverse established cardiac conditions. They undertook the present study to test the hypothesis that stress reduction would lead to better cardiovascular health in individuals with established ischemic heart disease.
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Hip fractures (hip) occur 2-4 times more commonly in persons who have sustained a stroke than an age-matched population.
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Valve replacement surgery is usually delayed until symptoms develop in patients with severe aortic stenosis by echocardiography. However, symptoms may be unreliable in older patients who are more sedentary. Thus, Gerber and colleagues from New Zealand evaluated the value of serial BNP measurements to predict the development of symptoms in 29 initially asymptomatic patients with moderate to severe aortic stenosis.
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The in-hospital outcomes of CABG patients were equivalent to non-CABG patients, suggesting that CABG remains a viable alternative to PCI in selected patients with ACS.
