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The first article summarizes the practical aspects of choosing an antibiotic in a patient with a reported drug allergy. The second describes the presence of K103 resistant virus in CSF but not in plasma.
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Mesial temporal sclerosis is the most common pathology found in surgical series of patients undergoing temporal lobectomy for pharmacologically intractable focal epilepsy. A better understanding of the mechanisms leading to this neuropathological substrate for temporal lobe epilepsy should provide fundamental insights into the pathophysiology of epileptogenesis.
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Although syncope is common, its epidemiology and prognosis have not been well described. Soteriades and colleagues, therefore, evaluated the incidence, causes, and prognosis of syncope among men and women taking part in the Framingham Heart Study.
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The high lifetime prevalence of depression in MS, along with other variants of mood disorder including anxiety and bipolar-affective illness, should make the psychiatric complications of MS a central component of disease management. These studies provide an additional understanding of depression and suicidal behavior in patients with MS.
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No single antigen has yet been identified as the target in all patients with chronic inflammatory demyelinating polyneuropathy, a presumed autoimmune disorder similar to chronic experimental allergic neuritis, where both humoral and cell-mediated immune responses have been documented. Evidence suggests that specific chemokines play a role in pathogenesis.
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While hypertension and smoking have been previously associated with aneurysmal subarachnoid hemorrhage, this is the first report of a role for coffee consumption. The methodology of the study, however, begs several further questions.
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In an extremely preliminary report, Mayer and associates present data on 5 patients with basilar artery thromboses treated with a device called Neuronet.
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Multiple system atrophy (MSA) is a neurodegerative disorder that can take protean forms. In this elegant paper, Tsuda and colleagues show that patients with the cerebellar form of MSA can be distinguished from idiopathic cerebellar degeneration before other signs of autonomic or parkinsonian disability develop.
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Metman and associates carried out a controlled trial using amantadine to determine whether they could ameliorate chorea. This was based on prior studies showing that N-methyl-D-aspartate antagonists such as dextrophan, dextromethorphan, and amantadine can alleviate levodopa-induced chorea inpatients with parkinsonism.
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Serial MRI measurements can be used to map the pattern of regional brain atrophy in a variety of neurologic disease states. Using robust techniques that minimize the subjectivity of morphometric analysis, Scahill and colleagues compared rates and regional distribution of brain atrophy in 4 presymptomatic patients, 10 with mild Alzheimers Disease (AD), 12 with moderate AD, and age-matched controls.
