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This meta-analysis of studies examining the efficacy of systemic corticosteroids for preventing laryngeal edema following extubation concludes that this treatment is effective. This result differs from those of several previous meta-analyses, and raises practical issues such as whether extubation should be delayed for at least 12 hours after a patient passes a spontaneous breathing trial and qualifies for extubation so that a course of steroids can be given.
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Ray et al examined the computerized files of Tennessee Medicaid recipients to estimate the effects of atypical antipsychotic drugs on the risk of sudden cardiac death.
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Deep brain stimulation significantly increases "on" time, reduces dyskinesias, reduces "off" time, and improves various quality-of-life measures compared with best medical therapy in patients with moderate to advanced Parkinson's disease.
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The spontaneous development of anti-amyloid antibodies may have an impact on the development of plaques and Alzheimer's disease.
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Postanoxic status epilepticus does not necessarily imply irreversible and fatal brain injury.
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Risk factors for spontaneous dissection of carotid and vertebral arteries include smoking, migraine, and a tall, thin body. Women are at increased risk of dissecting multiple arteries.
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When compared with conventional disease-modifying anti-rheumatic drugs (DMARD), tumor necrosis factor (TNF)-Alpha antibody treatment for rheumatoid arthritis (RA) may increase the risk of herpes zoster.
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The monoclonal antibody, rituximab, appears to benefit patients with myasthenia gravis that is refractory to other modalities.
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Individualization of therapy with pharmacogenetics; the rate vs rhythm debate; the FDA's Risk Evaluation and Mitigation Strategy; FDA actions.
