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Iloperidone is the newest atypical antipsychotic agent to be approved by the FDA. It is chemically similar to risperidone and ziprasidone. Vanda Pharmaceuticals will market iloperidone as Fanapt™.
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In elderly patients hospitalized with heart failure and LVSD, beta-blocker use was clinically effective in reducing mortality and rehospitalization, but patients with preserved systolic function had poor outcomes and beta-blockers did not significantly influence the mortality and rehospitalization rate for these patients.
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A variety of highly effective agents for primary insomnia are currently available including benzodiazepines, benzodiazepine receptor agonists, and other classes. Agents that impact the benzodiazepine receptors (i.e., either benzodiazepines or benzodiazepine receptor agonists) are controlled substances and have occasional problematic issues such as misuse, diversion, cognitive clouding, and rebound upon withdrawal.
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Microbiologists have traditionally taken extra steps to identify non-hemolytic streptococcus-like strains isolated from blood cultures primarily to identify Enterococcus species and rule out Streptococcus bovis. S. bovis is still often identified by its colony similarity to Enterococcus species and its similar ability to hydrolyze esculin in the presence of bile, but unlike Enterococcus species, it is unable to grow in 6.5% salt broth.
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A randomized, multicenter, open-label, parallel group, noninferiority trial of childhood septic arthritis was performed at seven referral hospitals in Finland from 1983-2005.
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In a series of elegant experiments, kohanski et al demonstrated that the three major classes of bactericidal antibiotics, regardless of drug-target interaction, stimulate hydroxyl radical formation in bacteria.
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Approximately 10% of international travelers are children (classified as those 18 years of age or younger in this study). As we note that more children are traveling, the number of malaria cases in travelers also is increasing.
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In the first study, patients with Hepatitis C Virus (HCV) genotype 1 infection were randomized to one of four treatment groups: pegylated interferon (pIFN) + ribavirin (RBV) given for 48 weeks + TPV placebo given for 12 weeks (PR48) or pIFN+RBV given for 12 weeks + telaprevir (TPV) given for 12 weeks (T12PR12) or pIFN+RBV for 24 weeks + TPV 12 weeks (T12P24) or pIFN + RBV for 48 weeks + TPV 12 weeks (T12P48).
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A cluster of febrile respiratory illness (FRI) associated with ad14 was reported at Lackland AFB, Texas in 2007. Combined surveillance and retrospective cohort investigation identified 1,147 basic military trainees with FRI; 551 (48%) were infected with Ad14. Of those, 23 were hospitalized with pneumonia, four required ICU admission, and one died.
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Hochedz et al from Paris, France, described 60 adult travelers diagnosed with skin and soft-tissue infections (SSTI) seen between January 1, 2006 and August 30, 2007.
