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The nurses' health study reported the risk of invasive breast cancer associated with the use of combined estrogen and testosterone. At the beginning of this cohort study, only 33 women reported testosterone use, but over the next 10 years this number increased to 550.
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While stress has well documented effects on immune, neurochemical and endocrinological function, its role in cancer progression is less well understood. It is appreciated, in preclinical studies, that stress can affect the growth of some tumors through modulation of the immune response to tumor cells.
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Hormone therapy is highly effective for relieving symptoms associated with menopause and for preventing postmenopausal osteoporosis. Some women, however, respond unsatisfactorily to standard doses of hormone therapy.
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There continues to be controversy regarding the merits and risks of one- or two-layer closure of the uterus during cesarean section. Also, although opinions abound concerning whether or not to close the peritoneum during a cesarean section, until now there has been sparse evidence in the literature to back either side.
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Angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce mortality and myocardial infarction (MI) in patients with heart failure due to reduced left ventricular (LV) systolic function.
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Discontinuation of anticoagulation 3-6 months after successful atrial fibrillation ablation is reasonable in low-risk patients.
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Among elderly persons without chronic kidney disease, cystatin C is a prognostic biomarker of risk for death, cardiovascular disease, and chronic kidney disease.
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A team from UCSF recently reviewed company documents that were entered into the public record as a result of litigation over the promotion of gabapentin (Neurontin) between 1994 and 1998.
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In ACS patients without persistent ST-segment elevation, there is a strong, consistent, temporal, and dose-related association between bleeding and death.
