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Outpatients with uncomplicated seasonal influenza were treated with single doses of IV peramivir 300 mg/kg, 600 mg/kg, or placebo. Peramivir significantly reduced the time to alleviation of symptoms at both doses compared with placebo. Peramivir was well-tolerated, and side effects were comparable to placebo.
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Using a quality improvement (QI) process, ICU delirium, physical rehabilitation, and functional mobility were significantly improved and associated with a decreased length of stay.
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The Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure is currently updating its work in JNC-7 in an effort to help physicians provide safe, effective, and patient-centered care for those with elevated blood pressure.
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Avian influenza has created an economic disaster in parts of Asia. While the number of associated identified human infections has, to date, not reached 100 cases, the possibility of a public health disaster looms since the outbreak of avian influenza may be setting the stage for the next human influenza pandemic.
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Samples obtained by swabbing both nares of almost 10,000 individuals > 1 year of age in the US National Health and Nutrition Survey (NHANES) in 2001-2002 were cultured on mannitol salt agar. S. aureus was identified in 32.4% of subjects and 0.8% were colonized with methicillin resistant S. aureus(MRSA).
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Adverse drug events (ADES) are unwanted consequences of drug therapy and have important implications for each patient, the treating physician, and the institution itself. When assessing adverse effects, prescribing healthcare workers should pay particular attention to ADEs that interrupt the patients therapeutic regimen and hence increase the patients length of stay in the hospital.
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The first article reports the results of an industry-sponsored clinical trial comparing TDF/ABC/3TC vs EFV/ABC/3TC in treatment-naïve patients. Three hundred forty patients were randomized. Baseline characteristics including CD4 count and HIV RNA level were similar between the arms.
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Tuberculin skin testing is a crude procedure, fraught with potential error at every step, from application to interpretation, and requires 2 visits to a health care provider. Its use has persisted, nonetheless, because it remained, until recently, the only means of detection of latent infection with Mycobacterium tuberculosis.
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More than 5000 people in the Comoros Islands, off the eastern coast of Africa and near Madagascar, became ill with high fever and severe joint paints in the first months of 2005.
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