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COVID-19 Rebound: To Retreat or to Re-Treat

Re-treatment of non-immunocompromised patients with mild-moderate COVID-19 rebound with nirmatrelvir/ritonavir provided no significant benefit.

Potential Benefit of Glyburide in Moderate-Volume Acute Ischemic Stroke

An exploratory analysis of the CHARM trial suggests intravenous glyburide may improve outcomes in large hemispheric stroke patients with infarct volumes < 125 mL, particularly alongside thrombectomy, reducing edema, mortality, and the need for decompressive surgery, and highlighting a potential neuroprotective role.

Acupuncture to Treat Low Back Pain in Older Adults

A multisite, three-arm, parallel-group randomized clinical trial of older adults in the United States with chronic low back pain found improvement in both pain and disability with the addition of acupuncture treatment compared to usual medical care alone.

Outpatient Management of Patients with VTE Diagnosed in the ED

Many low-risk patients with venous thromboembolism diagnosed in the emergency department can safely be treated outside the hospital. Studies show that outpatient management achieves similar outcomes to inpatient care in terms of recurrence and bleeding, while improving convenience and reducing healthcare costs.

Elamipretide Injection (Forzinity)

The U.S. Food and Drug Administration has granted accelerated approval to elamipretide, the first treatment for Barth syndrome — a life-threatening disease of the mitochondria. Elamipretide is a mitochondrial cardiolipin binder that improves mitochondrial structure and function.

Psychiatric Medications and Long QT Syndrome: A Safe Combination?

A retrospective study of patients with electrocardiogram long QT interval syndrome and psychiatric disease suggests that with proper pharmacologic treatment and counseling, the patients can be treated safely with psychiatric drugs known to increase the QT interval.

Measles Testing of Persons with HIV

A Dallas County human immunodeficiency virus clinic review from 2015-2025 found that only 11% of people with HIV had documented measles immunity, with younger patients, white and Hispanic patients, and patients with low CD4 counts more likely to be seronegative.

Repeated Head Impacts Are Associated with Tau Astrogliopathy

This study demonstrates that both traumatic brain injury and participation in contact sports are independently associated with increased tau astrogliopathy, particularly thorn-shaped astrocytes, even when cases of chronic traumatic encephalopathy neuropathologic change are excluded.

Efficacy of Adding Aspirin to OACs for CAD Patients

A randomized, placebo-controlled trial of adding aspirin to oral anticoagulant therapy in patients with chronic coronary artery disease at high risk of atherothrombotic complications and major bleeding was stopped early because aspirin increased the risk of all-cause mortality. In addition, aspirin was associated with an increase in atherothrombotic complications and major bleeding.

Detection of Atrial Fibrillation in Cryptogenic Stroke

The ANTARCTICA study is a pooled meta-analysis from multiple prospective studies of patients with ischemic stroke of varying etiologies, where loop monitoring was performed for atrial fibrillation detection. The groups were divided into cryptogenic stroke/transient ischemic attack or non-cryptogenic stroke/non-stroke. Both groups demonstrated an unadjusted rate of atrial fibrillation of about 30%.