Clinical
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MATRIX Reloaded: Bivalirudin Fails to Best Heparin in ACS
Among patients with acute coronary syndromes referred for percutaneous intervention, bivalirudin did not lower rates of major adverse cardiovascular events or net adverse clinical outcomes as compared with unfractionated heparin.
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A Revolution in Pacing?
Leadless pacemakers appeared to be effective and relatively safe in short-term follow-up.
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Clinical Briefs
In this issue: preventing recurrence of depression; predicting which patients with non-alcoholic fatty liver disease will progress; and treating premature ejaculation with tramadol.
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Cryptogenic Stroke and Atrial Fibrillation
Recent study results support monitoring patients > 60 years of age with evidence of prior stroke on brain imaging to look for atrial fibrillation.
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Alirocumab Injection (Praluent)
Alirocumab provides a new mechanism of action for lowering cholesterol in patients who have not achieved adequate lowering on maximum dose of statins.
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Migraine and Cognitive Dysfunction
During an attack of migraine without aura, patients may experience transient cognitive impairment, with predominant involvement of verbal processing speed, learning, and memory, due to reversible cortical dysfunction.
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Is Low Testosterone Therapy Worth the Hype in the Elderly?
Testosterone replacement therapy showed no impact on subclinical atherosclerosis progression in recent study.
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SGLT2 Inhibitors: Now The Bad News
Sodium-glucose cotransporter-2 inhibitors are approved as adjunctive therapy for the treatment of patients with type 2 diabetes. This drug class has been also used off-label to improve glycemic control in patients with type 1 diabetes.
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Morcellation: Has it Improved Outcomes or Put Women at Risk?
Widespread concern over malignant tumor dissemination with morcellation threatens to undermine advances in minimally invasive gynecologic surgery that have benefited women. Before providers abandon this technique, they should put the risks and benefits in perspective.
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Can Cerebroplacental Ratio Predict Neonatal Mortality?
Recent articles show the cerebroplacental ratio to be a useful predictor of immediate and later neonatal morbidity, particularly, in late-onset intrauterine growth restriction.