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Requiem for Beta-blockers Post-Myocardial Infarction?
A propensity score analysis of all hospital survivors of acute myocardial infarction in the United Kingdom from 2007-2013 showed that one-year survival in hospital patients without heart failure or left ventricular dysfunction treated with beta-blockers did not differ from survival in those patients not so treated.
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Obesity: The New Epidemic
Obesity has risen significantly worldwide and is associated with an increased risk of morbidity and mortality in women throughout their lives. Risks include infertility, gestational diabetes, type 2 diabetes, heart disease, and cancer.
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AUGS Consensus Statement: Anticholinergic Medication Use and Cognition in Women With Overactive Bladder
Available evidence has shown significant associations between anticholinergic medication use and increased risk of cognitive impairment. Behavioral therapies for overactive bladder should be first-line treatment. If these treatments fail and pharmacologic treatment is considered, providers should counsel patients on associated risks, prescribe the lowest effective dose, and consider alternative treatments in patients at risk.
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Opioid Prescriptions After Cesarean Delivery: How Much Should We Prescribe?
This cross-sectional survey of 720 women found that 85% filled an opioid prescription after cesarean delivery, and the median number of tablets dispensed was 40. The median number of tablets consumed was only 20 tablets and the number dispensed did not correlate with patient satisfaction, pain control, or the need for a refill.
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Clinical Briefs
In this section: Use caution with a nocturia treatment; an analysis of a cellulitis remedy; and handling influenza patients.
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Sarilumab Injection (Kevzara)
Sarilumab is indicated for the treatment of adults with moderately to severely active rheumatoid arthritis who have demonstrated an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs.
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Possible Benefit From Pharmaceutical-grade Chondroitin on Knee Osteoarthritis
The authors of a European study found a statistically significant and clinically marginally significant reduction in pain at three and six months in patients taking pharmaceutical-grade chondroitin sulfate for knee osteoarthritis.
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Glucose Self-monitoring May Not Be That Useful
Researchers could not find any statistically significant differences in glycemic control or health-related quality of life between patients who performed glucose self-monitoring compared with those who did not.
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Early Hot Flashes Could Signal Increased Risk for Heart Disease
Women 42-55 years of age who experience hot flashes are more likely to exhibit poor vascular function.
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FDA Actions
In this section: New FDA commissioner off to fast start on opioids, drug safety, and orphan drug designation.