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The authors investigated invasive breast cancer incidence and mortality after a total follow-up of 11 years among the 16,608 postmenopausal women aged 50-79 years with no prior hysterectomy who were randomized to combined oral conjugated equine estrogens (0.625 mg/day) plus medroxyprogesterone acetate (2.5 mg/day) or placebo in the Women's Health Initiative (WHI) HRT study. In the initial reports from the WHI HRT study, breast cancer incidence was increased (hazard rate [HR], 1.26; 95% confidence interval [CI], 1.00-1.59).
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For many years we have been pushing the concept that the earlier that prenatal care is initiated, the better will be the outcome. Since there are certainly data proving that late enrollment makes for worse outcomes, this "the-earlier-the-better" mantra has almost attained bumper sticker status.
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It seems that at least twice a week we either inadvertently find, or have a pregnant patient referred with a band-like structure that runs north-to-south between the uterine walls. In a non-pregnant uterus this would be called a synechium, but the most common label assigned to this finding in pregnancy is a "sheet."
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A study group of 98 patients were enrolled through seven centers to evaluate the efficacy of sildenafil in the treatment of sexual dysfunction associated with the use of selective and nonselective serotonin reuptake inhibitors (SRIs).
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In this issue: Tiotropium for uncontrolled asthma, sibutramine pulled from market, incidence and mortality data from WHI, FDA Actions.
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Peripheral nerve involvement is common in systemic amyloidosis and may be the initial clinical manifestation.
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Although subthalamic nucleus stimulation can improve motor functions in Parkinson's disease, this study showed that it degrades somatosensory temporal discrimination possibly by modifying central somatosensory processing.
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Fabry disease, while rare across the general population, is not rare as a cause of small fiber neuropathy.
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Children with H1N1 influenza are more likely to have neurologic complications compared to those with non-N1H1 seasonal influenza
