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Is It Better to Up-Titrate Medications Faster in Acute Heart Failure Patients?
Early intensive up-titration of guideline-recommended therapy in patients admitted for heart failure reduced 180-day readmission and all-cause mortality rates at the cost of more adverse events (but not serious or fatal ones).
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Low-Fat vs. Mediterranean Diet for Secondary Prevention
A study of stable coronary heart disease patients comparing the Mediterranean diet to a low-fat diet over a seven-year follow-up showed the Mediterranean diet was superior at preventing major cardiovascular events.
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Efficacy and Safety of Leriglitazone in Patients with Friedreich Ataxia
Friedreich ataxia (FRDA) is an autosomal, recessive, multisystemic disease characterized by progressive weakness, ataxia, and dysarthria starting in childhood and resulting in severe morbidity and premature death. There are no approved treatments for FRDA. With recent preclinical studies suggesting potential benefit of PPARPγ agonists in motor function and reduced radiographic disease activity, the current study explores the effect of leriglitazone, a PPARPγ agonist, in patients with moderate to severe FRDA.
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Late-Onset Pompe Disease: A Review of Clinical Features
In this systematic literature review of studies that evaluate motor and locomotion function in patients with adult, late-onset Pompe disease, the clinical spectrum reveals weakness of respiratory, axial, and proximal limb muscles.
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Can a Blood-Based Test Serve as a Biomarker for Parkinson’s Disease?
This proof-of-concept study proposes that a noninvasive assay detecting pathology-associated α-synuclein extracted from blood may reveal a reliable biomarker for Parkinson’s disease.
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Do Spinal Cord Stimulators Really Help for Chronic Pain?
A comprehensive analysis of a large clinical database regarding treatment of patients with chronic low back pain did not support the benefit of spinal cord stimulators compared to conventional medical management for chronic pain.
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Magnetic Brain Stimulation for Alzheimer’s Disease
Transcranial magnetic stimulation, targeted at the precuneus in an effort to maintain a normal default mode network, shows some promise in slowing cognitive decline and maintaining normal electrophysiology in patients with mild to moderate Alzheimer’s disease.
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An Easy Measure of Potentially Harmful Salt Intake
Those who rarely or never added salt to their food and strongly adhered to the Dietary Approaches to Stop Hypertension diet exhibited the lowest incidence of subsequent cardiovascular disease.
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Is Chlorthalidone Superior to Hydrochlorothiazide for Treating Hypertension?
Randomly switching half of patients with hypertension on hydrochlorothiazide to chlorthalidone did not produce any difference in major cardiovascular outcomes.
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Ablation vs. Drug Therapy for Atrial Fibrillation, Revisited
A three-year follow-up of EARLY-AF, a study of relatively young and healthy patients with recent atrial fibrillation, showed cryoablation remains superior to drug therapy for preventing the development of persistent atrial fibrillation.