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The use of non-steroidal anti-inflammatory drugs (NSAIDs) early after myocardial infarction (MI) has been shown to increase the risk of death or recurrent MI, but little is known about the long-term risks. Thus, this group from Denmark evaluated their national database and identified more than 99,000 patients who survived 30 days after discharge following their first MI.
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This study reports data from the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) on the clinical characteristics of infective endocarditis related to pacemakers and ICDs. ICE-PCS collected data on 3284 patients with endocarditis from 64 centers in 28 countries in a central database.
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Linezolid was non-inferior to vancomycin in patients with nosocomially acquired MRSA pneumonia. Although mortality was similar among linezolid- and vancomycin-treated patients, several outcomes (such as clinical cure and microbiological cure) favored linezolid.
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Institution of a formal audit and feedback program resulted in a decrease in use of broad-spectrum antibiotics and a 31% reduction in cases of Clostridium difficile infection.
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This comprehensive review on postoperative patient handoffs confirms that they are high-risk events associated with adverse patient outcomes, and permits the identification of several strategies likely to improve the process despite the incompleteness and other limitations of the existing literature.
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This study of 537 hospitals found that those with the lowest mortality rates for acute myocardial infarction have management strategies that differ in important ways from those at hospitals with higher acute myocardial infarction mortality.
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In a retrospective, propensity-score-matched, case-control study, investigators compared clinical outcomes and drug tolerabilities between nafcillin and cefazolin in the treatment of MSSA bacteremia. The authors found that cefazolin was as efficacious as nafcillin in the treatment of MSSA bacteremia while causing fewer adverse drug events.
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Refining the Relationship Between Thyroid Hormones and Left Ventricular Mass; The ORIGIN Trial: Basal Insulin vs Standard Care for Early Type 2 Diabetes; Bronchodilators in COPD and Arrhythmias; Reversible Dementia from Corticosteroid Therapy; Could Thinner be Worse for Newly Diagnosed Diabetics?; The Impact of Exercise on Depression in Heart Failure
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Approximately 20% of patients with unprovoked venous thromboembolism (VTE) have a recurrence within 2 years after the withdrawal of oral anticoagulant therapy.
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Coffee is widely consumed throughout the United States. Some prior studies have associated coffee consumption with increased rates of heart disease, whereas other studies have shown less heart disease in coffee drinkers. The data associating coffee consumption and total mortality have also been conflicting.
