Browse Clinical Publication Articles by Topic

Cirrhosis and Infections

Infections in patients with cirrhosis are frequent and potentially lethal, with pneumonia associated with the highest risk for mortality.

Are SGLT2 Inhibitors Effective for HFpEF Patients Without Diabetes?

After comparing empagliflozin to placebo for patients with heart failure and preserved left ventricular ejection fraction, researchers found no differences in the significant reduction of the primary outcome of cardiovascular death or heart failure hospitalization over 36 months based on whether patients were diabetic.

Rivaroxaban Monotherapy for Atrial Fibrillation in Coronary Artery Disease Patients

For patients with atrial fibrillation and stable coronary artery disease, rivaroxaban monotherapy was superior to dual therapy for preventing thrombotic and bleeding events and was associated with a lower mortality rate.

The Value of Stress Testing in Patients with Known Coronary Artery Disease

A comparison of adenosine stress single-photon emission CT, PET, and MRI in stable patients with known coronary artery disease (CAD) showed PET to be more sensitive for detecting invasive fractional flow reserve-identified ischemic lesions. However, the sensitivity was disappointing. Patients with known CAD and new symptoms should be referred directly to invasive coronary angiography.

Predicting the Tolerability of Sacubitril/Valsartan in Advanced Heart Failure

An analysis of the sacubitril/valsartan run-in period for chronic, advanced heart failure patients showed 18% could not tolerate the lowest dose, usually because of hypotension or renal dysfunction. Investigators identified six predictors of non-tolerance, which may help clinicians choose the best candidates.

Are SGLT2 Inhibitors Effective for HFpEF Patients Without Diabetes?

After comparing empagliflozin vs. placebo for patients with heart failure and preserved left ventricular ejection fraction, researchers found no differences in the significant reduction of the primary outcome of cardiovascular death or heart failure hospitalization over 36 months based on whether patients were diabetic.

What Do You Think Happened?

You are asked to interpret the tracing in the figure without the benefit of any history. What do you think happened? How acute are these findings?

Baricitinib Tablets (Olumiant)

Baricitinib is the first FDA-approved systemic treatment of alopecia areata.

Comparing CT Angiography to Invasive Angiography for Stable Chest Pain Patients

A trial of initial coronary CT angiography vs. invasive angiography revealed outcomes over a median 3.5-year follow-up were similar, but procedure-related complications were more common in the invasive group.

Is the Canadian Syncope Risk Score Valid?

Researchers found the Canadian Syncope Risk Score accurately predicts which patients are low risk for discharge. However, since it is driven largely by the physician’s final risk classification at ED discharge, the score’s clinical utility is uncertain.