Cardiology
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Importance of Exercise Testing-Associated Ventricular Ectopy
A study of asymptomatic subjects without known cardiovascular disease undergoing treadmill exercise testing and followed for a mean of 20 years showed high-grade premature ventricular contractions during exercise recovery (but not during exercise) are predictive of subsequent cardiovascular mortality.
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Post-TAVR Patients with Atrial Fibrillation Bleed Less on Vitamin K Antagonists vs. Edoxaban
In this randomized trial of post-transcatheter aortic valve replacement patients with atrial fibrillation, edoxaban was noninferior to vitamin K antagonists with regard to a composite of adverse endpoints, but was associated with a higher rate of major bleeding.
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New Treatment for Hypertrophic Obstructive Cardiomyopathy
A study of the echocardiographic characteristics of symptomatic patients with obstructive hypertrophic cardiomyopathy treated with mavacamten showed a persistent 30-week improvement in several key pathophysiologic characteristics.
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Post-Exercise Premature Ventricular Contraction, or Aberrancy?
The ECG in the figure is a post-exercise tracing. There are four wider and slightly early occurring beats in the long lead rhythm strips. Are these beats premature ventricular contractions or premature atrial contractions conducted with aberration?
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Nirmatrelvir and Ritonavir Tablets (Paxlovid)
The FDA has issued an emergency use authorization for the first oral regimen for the treatment of COVID-19.
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Incidence, Prevalence, and Long-Term Consequences of Small Fiber Neuropathy
Small fiber neuropathy (SFN) associated with diabetes and other causes is more likely to progress to large-fiber polyneuropathy, deteriorate faster, and cause worse disability vs. slow progression with idiopathic SFN.
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Coronary CT Angiography in the General Population
Coronary artery CT angiography in asymptomatic, middle-aged subjects without known coronary artery disease showed coronary atherosclerosis is common but mostly mild and appears in women after a 10-year delay.
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Fish Consumption, Omega-3 Fatty Acids, and Cardiovascular Disease
Is there enough scientific evidence to suggest associations between fish consumption and risk of cardiovascular disease (or of mortality) among people who consume fish vs. those who do not?
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Drinking More Coffee May Protect Against Cognitive Decline
Among adults older than age 60 years, heavier coffee consumption was associated with slower cognitive decline in executive function and less beta-amyloid accumulation.
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Dietary Modifications with Linoleic Acid Can Have an Effect on Gut and Brain Inflammation
This study will widen the scope of discussion on the treatment of neurological disorders. Nutritional supplements need to be discussed with caution until clear recommendations can be given based on clinical trials and other strong evidence of efficacy without significant side effects.