Cardiology
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Oteseconazole Capsules (Vivjoa)
The FDA has approved the first drug to reduce recurrent vulvovaginal candidiasis.
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Neurodegeneration Biomarkers in Patients with Subjective Cognitive Complaints
In individuals with subjective cognitive decline, multiple biomarkers of neurodegeneration were found to add predictive values beyond amyloid and tau biomarkers.
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Does Amantadine Treatment Reduce Levodopa-Induced Dyskinesias?
Early treatment with amantadine may delay levodopa-induced dyskinesia onset more than treatment with other symptomatic agents.
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COVID-19 Associated with Significant Increase in Hospital-Acquired Bloodstream Infections
The COVID-19 pandemic was associated with increases in hospital-onset bloodstream infections, mainly in patients with COVID-19.
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Dose-Response Relationships Between Exercise, Exercise Intensity, and Mortality
The authors of this review of eight studies with 36,383 participants looked at objective measurements of physical activity, finding a dose-response association between any level of activity and reduced risk of death and between more sedentary time and higher risk of death.
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Galactagogues in Breastfeeding: A Review of the Available Evidence
This is a review of the research that has gone into nearly a dozen common galactagogues. An examination of the available randomized, controlled trials and review papers reveals a lack of high-quality research but also offers recommendations to help breastfeeding parents.
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Report: Pregnancy-Related Hypertensive Disorders Doubled in 12 Years
An estimated one in five births in the United States are affected by various adverse pregnancy outcomes.
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Mortality and Days Alive Outside Institutions in Older Patients After Tracheostomy with or Without Gastrostomy Tube
Medicare beneficiaries who underwent tracheostomy and gastrostomy tube placement often remained institutionalized beyond three months, with three-, six-, and 12-month mortality greater than 40%, 50%, and 60%, respectively.
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Occult Hypoxemia Is More Common in Black Patients than in White Patients About to Undergo ECMO for Respiratory Failure
In this retrospective analysis of de-identified Extracorporeal Life Support Organization registry data, the prevalence of occult hypoxemia was higher in Black patients than in white patients. Hispanic and Asian patients had a similar prevalence of occult hypoxemia compared to white patients.
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Surviving Sepsis: The New Guidelines
Subsequent revisions of Surviving Sepsis guidelines highlighted the need for early, appropriate antibiotics along with a new focus on initial resuscitation, stressing the importance of dynamic measurements instead of static variables to predict fluid responsiveness. The most recent 2021 revisions continue to stress the importance of these ideals, but they also place an increased emphasis on the hour-1 bundle and improving the care of sepsis patients after they are discharged from the intensive care unit.