Cardiology
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Is the Combination of a GLP-1 Agonist and a SGLT2 Inhibitor Safe?
An analysis of the Harmony Outcomes study and a meta-analysis combining it with the AMPLITUDE-O study of the addition of a glucagon-like peptide 1 receptor agonist (GLP-1 RA) in a subgroup of type 2 diabetes patients on baseline sodium-glucose cotransporter-2 (SGLT2) inhibitor therapy has shown that major adverse cardiovascular events are reduced by GLP-1 RA, regardless of baseline SGLT2 use, and there was no difference in serious adverse events.
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Tachycardia in the Emergency Department: Part II
This issue completes the two-part series on tachycardia. This issue will finish the discussion of additional causes of tachycardia, address management, and conclude by covering some challenging issues with this arrhythmia.
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How Many Steps a Day Will Improve Patients’ Longevity?
A systematic review and meta-analysis of studies of the association of step counts and cadence with all-cause mortality and cardiovascular events showed the benefits in these outcomes are statistically significant, at about 2,600 steps/day and peak at about 8,000 steps/day. Also, faster step cadence augments these benefits.
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Coronary CT Angiography in Patients with Type 2 Myocardial Infarction
In an observational, single-center study of patients with type 2 myocardial infarction who underwent coronary CT angiography, researchers reported fewer than half had a significant anatomic stenosis (50% or greater), but only 26% had a hemodynamically significant lesion by CT fractional flow reserve.
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Risk of Incidental Coronary Calcium on Chest CT Scans
A deep learning-derived algorithm for measuring coronary artery calcium scores in non-ECG-gated, non-contrast chest CT scans ordered for non-cardiac reasons was predictive of death and adverse atherosclerotic cardiovascular events. This may provide an opportunity for earlier prevention interventions.
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What Coronary Artery Calcium Score Signifies Secondary Prevention?
A large registry study of individuals without known cardiovascular disease but with known coronary artery CT calcium scores showed those with an Agatston score higher than 300 are at risk of experiencing major cardiac events similar to patients with known cardiovascular disease over five years.
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Tachycardia in the Emergency Department: Part I
This issue is the first of a two-part discussion of tachycardia, the most common rhythm abnormality seen in the emergency department. Part I will discuss the epidemiology, etiology, and characteristics of the different tachycardic arrhythmias. Part II will discuss conditions affecting other organ systems that can produce tachycardia, then finish by reviewing the assessment and management of these patients. We hope these two issues will be useful to your clinical practice.
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Integrating Reproductive History Could Help Postmenopausal Women’s Long-Term Brain Health
Researchers observed patients with higher cumulative estrogen exposure throughout their life may be at lower risk of developing cerebral small vessel disease.
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Is the Irregularity a Problem?
Interpreting ECGs without the benefit of any history always is challenging. Such is the case with the figure in this article, which manifests significant irregularity.
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Timing of Anticoagulation Administration Following Atrial Fibrillation-Associated Stroke
A prospective, blinded, randomized study of early vs. later administration of oral anticoagulation after ischemic stroke in patients with atrial fibrillation calibrated by cerebral imaging showed no significant difference in 30-day outcomes.