Bacterial Infections
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Limiting Testing in Febrile Young Infants with Abnormal Urinalyses
According to a 26-site study, febrile infants younger than 2 months of age who have abnormal urinalyses are at very low risk of having meningitis and might not necessarily need to be subjected to lumbar puncture.
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Better Diagnostics Equals Fewer Unnecessary Antibiotic Prescriptions
Researchers credit diagnostic stewardship as the top reason for an impressive reduction in needless antibiotic prescriptions.
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Cellular Tests Are Not Accurate for Diagnosing Lyme Disease
A prospective case-control study from the Netherlands evaluated three cellular tests for diagnosing Lyme disease. All three had low specificity compared to serological testing, leading to an unacceptably high number of false-positive results.
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Antibiotic Resistance: We Were Doing Great and then COVID Happened
After improvement, antimicrobial resistance in the United States significantly increased.
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An Unhealthy Gut Microbiome May Cause Colorectal Cancer
An E. coli variant found in the Western diet was associated with a higher incidence of colorectal cancer.
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Melioidosis May Be Acquired by Exposure to Contaminated Soil in the Gulf Coast of the United States
Exposure to contaminated soils in the U.S. Gulf Coast is a risk factor for acquiring melioidosis.
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COVID-19 Exacerbated Antimicrobial Resistance
CDC report indicates related infections and deaths rose 15% in hospitals in 2020.
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Oral Tebipenem: A New Antibiotic for Multidrug-Resistant, Gram-Negative Complicated Urinary Tract Infections
A randomized clinical trial that compared oral tebipenem with intravenous ertapenem in patients with complicated urinary tract infection or acute pyelonephritis found tebipenem to be noninferior in efficacy. The safety profile was similar between the two drugs.
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Infectious Disease Alert Updates
Recovering from Critical COVID; Oral and Anal Transmission of Syphilis
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Immunosuppressants and the Risk for Clostridioides difficile Infection
A retrospective cohort study found that for patients taking immunosuppressing medications, the greatest risk for C. difficile infection occurred for those receiving calcineurin inhibitors and those taking drugs from multiple immunosuppressant classes.