Articles Tagged With:
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Patients Hospitalized for Non-Severe COVID-19: No Benefit of CAP Antibiotics
A large population-based, retrospective, cohort study found there was no benefit for antibiotics targeting community-acquired pneumonia in patients hospitalized with non-severe COVID-19. These results provide evidence against antibiotic use in this population.
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Weight Loss Without Bone Loss: Mediterranean Diet and Exercise in Older Women
This systematic review found that, among older women undergoing intentional weight loss, bone density is better preserved with a calorie-restricted Mediterranean diet combined with physical activity, compared to a standard Mediterranean diet alone.
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Wrist and Finger Dislocations
Injuries to the wrist and fingers, although frequently overshadowed in polytrauma care, demand precise assessment and timely intervention to prevent long-term functional impairment. In this issue, the authors provide a thorough and clinically focused review of these often-complex dislocations, emphasizing both anatomical understanding and evidence-based management strategies relevant to emergency medicine providers.
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Telisotuzumab Vedotin-tlly (Emrelis)
The U.S. Food and Drug Administration has granted accelerated approval of telisotuzumab vedotin-tilly, a first-in-class c-mesenchymal-epithelial transition factor-directed antibody and a microtubule inhibitor conjugate for the treatment of locally advanced or metastatic, non-squamous non-small cell lung cancer.
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24-Hour Activity Rhythms and Amyloid-β Deposition in the Brain
This study of dementia-free adults found that greater variability of the 24-hour activity rhythm (greater during the daytime as well as during sleep time) with fragmentation of sleep predicted increased deposition of amyloid-β (Aβ), especially in apolipoprotein E 4 (APOE4) carriers.
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New Injectable Cholesterol-Lowering Drug Trial
A comparison of inclisiran therapy to placebo and ezetimibe therapy over six months in primary prevention patients at low risk of atherosclerotic cardiovascular disease and not taking lipid-lowering therapy has shown that inclisiran subcutaneously every six months reduces low-density lipoprotein cholesterol more than ezetimibe and is comparable to the reported results of high-dose statins taken daily.
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CT Coronary Artery Calcium Progression After an Initial Score of Zero
A large Korean study of asymptomatic subjects undergoing more than one computed tomography (CT) coronary calcium scoring scan as part of an employment-based health screening has shown that most had scores of 0, and that during a maximum follow-up of 12 years, the majority stayed at 0 on a repeat scan. Also, in those with a coronary artery calcium score of 0 initially, clinically significant scores (> 100) were only found in 4% of scans at 10-year follow-up.
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Are Weight Gain and Mental Health Bidirectionally Connected?
In an adult population-based cohort study over four years, researchers found that both emotional eating and body dissatisfaction independently mediate the relationships between mental health factors and body mass index trajectories.
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Pediatric Airway Management: Difficult Airways
One of the most critical aspects of pediatric emergency medicine is handling a critical airway in a child. The authors provide comprehensive guidance on preparation, recognition and management to achieve success in this challenging situation.
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Post-Traumatic Headaches: Common and Complicated
The brain’s ability to modulate pain influences the development and persistence of post-traumatic headache (PTH). Functional magnetic resonance imaging (fMRI) studies in people with PTH show higher pain-induced brain activation in specific regions, such as the postcentral gyrus, superior temporal gyrus, and ventral striatum, as compared to healthy controls. Over 16 weeks of observation, progressive normalization in pain-induced brain activation was seen in the PTH group with headache improvement, with persistently elevated activation in the non-improvement PTH group.