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ANPRM Update
The U.S. Department of Health and Human Services published a Notice of Proposed Rulemaking at press time in the Office of the Federal Register.
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AllTrials launches U.S. campaign, demands clinical trial data release
Originally founded in the UK, the AllTrials Campaign have brought their crusade for clinical trial transparency to the United States.
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Two Drugs Better Than One for Pulmonary Arterial Hypertension
Among subjects with pulmonary arterial hypertension who are treatment naïve, initial combination therapy with tadalafil and ambrisentan is associated with significantly lower risk of clinical failure than initial monotherapy with either tadalafil or ambrisentan.
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Role of Transthoracic Echo in Staph Bacteremia
In patients without community-acquired Staph bacteremia, a high-risk cardiac condition, or IV drug use, a negative transthoracic echo excluded infective endocarditis.
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Echocardiographic Parameters Predict Outcome in Peripartum Cardiomyopathy
Poor baseline left ventricular ejection fraction, greater degree of left ventricular dilation, and black race predict poorer subsequent recovery with conventional therapy.
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MATRIX Reloaded: Bivalirudin Fails to Best Heparin in ACS
Among patients with acute coronary syndromes referred for percutaneous intervention, bivalirudin did not lower rates of major adverse cardiovascular events or net adverse clinical outcomes as compared with unfractionated heparin.
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A Revolution in Pacing?
Leadless pacemakers appeared to be effective and relatively safe in short-term follow-up.
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Clinical Briefs
In this issue: preventing recurrence of depression; predicting which patients with non-alcoholic fatty liver disease will progress; and treating premature ejaculation with tramadol.
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Cryptogenic Stroke and Atrial Fibrillation
Recent study results support monitoring patients > 60 years of age with evidence of prior stroke on brain imaging to look for atrial fibrillation.
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Providers must tread carefully if patient objects to caregiver
Recent racial controversies have prompted some risk managers to wonder how to respond if a patient objects to the race, gender, religion, or sexual orientation of a caregiver.