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Increased migraine attack frequency and overuse of acute medication, especially barbiturates and opiates, are risk factors for the chronification of migraine, which occurs in up to 2% of individuals.
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Two animal models of dystonia reveal that cerebellar activity influences abnormal involuntary dystonic movements, and implicate dysfunction of a cerebellar-striatal network in the development of dystonia.
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Platelet function testing identifies patients who do not respond to antiplatelet therapy and are at increased risk for acute stent thrombosis after neurointerventional procedures.
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The Babinski sign continues to be a valid bed-side test for pyramidal tract lesions.
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The anti-angiogenic monoclonal antibody, bevacizumab, shows great promise in the treatment of malignant gliomas.
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Some women with DVT may stop warfarin after six months; Vytorin and cancer; preventing recurrent stroke; and FDA news.
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A prospective analysis of an established epidemiological cohort indicated a significant risk of developing subsequent malignancy among those with compared to those without established non-melanoma skin cancers. The increased risk was apparent even after adjustment for confounding variables such as age, sex, smoking history, socioeconomic status, and sun exposure.
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Chemotherapy for advanced biliary tract cancers has been of only marginal value, in terms of objective response rates and improved survival. To assess whether chemotherapy with gemcitabine and capecitabine could effect improved quality of life and diminished symptoms, Koeberle et al performed a phase II trial using patient reported outcomes such as pain relief, physical performance and change in body weight, as outcome measures. The gemcitabine/ capecitabine combination did result in a significant improvement in these measures in about one-third of cases, and stability in those measures in another one-third. In terms of palliation, this combination appears to an effective choice.
