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In this issue: Apixaban could soon join the anticoagulation market; Chinese herbs for flu; chronic medication and discontinuation after hospitalization; and FDA actions.
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A total of 130 singleton stillbirths from a single institution in Australia, from January 2005 through December 2006, of > 20 weeks gestation with no cause of death and with available formalin-fixed, paraffin-embedded tissues were examined by multiplex PCR for 19 infectious agents, and by immunohistochemistry for human cytomegalovirus (CMV).
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The authors conducted a series of experiments in which HIV-1 transfected 1G5 T cells were exposed to either a series of known long terminal repeat (TLR) ligands (FimH/TLR-4, flagellin/TLR-5, and poly I:C/TLR-3) or STI pathogens (HSV-1, HSV-2, and N. gonorrhoeae).
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Physicians at the University of California-San Diego (UCSD) report a cluster of 5 cases of cutaneous Leishmaniasis in illegal immigrants from East Africa, which surprisingly turned out to be consistent with New World Leishmaniasis, although all 5 had come from an area endemic for Old World Leishmaniasis. How did this occur?
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Add Tdap to the growing list of recommended (and often required) vaccinations for health care workers (HCWs) in hospital, including MMR, hepatitis B, influenza, and possibly varicella. In April, the American College of Immunization Practices (ACIP) issued provisional recommendations for pertussis vaccination (Tdap) of all hospital HCWs, regardless of age and prior vaccine history (i.e., regardless of the time since last Td dose).
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In the ICUs of a well-staffed academic medical center committed to quality improvement, in which closed staffing, multidisciplinary rounds, and the daily use of checklists were already in place, implementation of a 24-hour ICU telemedicine system that was well accepted by the medical staff was associated with impressive improvements in adherence to best practice standards as well as with reductions in hospital mortality and lengths of stay.
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The authors advocate that cardiovascular magnetic resonance imaging using specific criteria may be useful as a diagnostic tool for patients with stress cardiomyopathy at the time of acute clinical presentation.
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In this study, the authors attempt to develop a risk stratification score to predict bleeding in patients treated with warfarin oral anticoagulation.
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Intensivists experienced significantly less burnout, work-home life imbalance, and job distress under an interrupted schedule vs a continuous (half-month) schedule. ICU length of stay and mortality were non-significantly higher under continuous scheduling.
