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In a multicenter trial of anemic head and neck cancer patients, recombinant human erythropoietin (epoetin b) or placebo were administered as adjuncts to radiation therapy. As expected, hemoglobin levels rose in the epoetin-treated patients, but locoregional control and survival were diminished. This surprising result warrants prompt confirmatory study and expanded investigation to determine mechanism.
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The data in this case-control study of combined estrogen plus progestin therapy revealed an increased risk of breast cancer, particularly invasive lobular tumor, regardless of whether the progestin component was taken sequentially or continuously. There was no increased risk of breast cancer in those exposed postmenopausally to estrogen only.
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Only 5% of white women and 0.6% of black women are potential candidates for tamoxifen chemoprevention.
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The FDA has approved Pfizer's eplerenone (Inspra) for the treatment of congestive heart failure (CHF) in patients who have sustained a myocardial infarction.
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Although vasculitic diseases generally are uncommon in the pediatric population, early recognition of processes that do occur is important to prevent sequelae. The authors provide a comprehensive review of the most common vasculitic diseases in children, with an emphasis on diagnostic clinical features, key laboratory studies, and appropriate therapy.
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This is the first study to examine whether nuclear transfer stem cells are effective in an animal model of Parkinsons disease. Nuclear transfer is a means of creating stem cells that are genetically identical to the donor.
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West Nile virus may present as meningitis, encephalitis, meningoencephalomyelitis, and Guillain Barré syndrome. Poliomyelitis, as 2 well-documented cases demonstrate, must also be added to the list.
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Helmstaedter and colleagues addressed the question of whether temporal lobe epilepsy may be associated with cognitive decline.
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