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In this randomized, double-blind trial, a total of 213 patients with relapsing-remitting or relapsing secondary progressive multiple sclerosis were assigned to 1 of 3 groups: natalizumab at 3 or 6 mg/kg (68 and 74 patients, respectively), or placebo (71 patients), by infusion every month for 6 months.
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The publication of the ALLHAT trial received much publicity not only in medical circles but was also front-page news in the Wall Street Journal. This trial was a significant blow to the pharmaceutical industry, and it convincingly showed that inexpensive diuretic medications had superiority over highly marketed ACE inhibitors and calcium channel blockers for the treatment of hypertension.
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Three recent studies have provided further evidence linking elevated homocysteine levels to brain atrophy and cognitive dysfunction, as well as a decline in physical function.
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ALLHAT: Thiazide for Hypertension Treatment; Candesartan Effective Against Migraines; Cough! No Cold Relief from Echinacea; COX-2 Inhibitors and GI Benefits Could Be Overrated; FDA Actions
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Two means of transmission of West Nile virus are newly describedsharps injury and transplacental infection.
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Evidence indicates that a novel paramyxovirus, the human metapneumovirus, may be an important cause of respiratory tract infection.
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A study of all children born in Denmark from 1991-1998 showed no association between vaccination with measles, mumps, and rubella (MMR) vaccination and autism.
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Genetic mutations associated with resistance to fluoroquinolones were frequently detected in MRSA.