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Telemedicine for Managing Patients with Epilepsy
This retrospective study found telemedicine (TM) visits to be noninferior to in-person (IP) visits for key outpatient epilepsy care outcomes, including medication adjustment, surgery discussions, and avoiding emergency visits. TM was less effective for assessing the neurologic exam, and seizure freedom rates were inconclusive with respect to noninferiority. Although not a full replacement for IP care, TM remains an effective option since its future in healthcare delivery is being reassessed in the wake of the COVID-19 pandemic.
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Medications for Women Aged 10 to 50 Years with Idiopathic Generalized Epilepsy
After failure of first-line anti-seizure medication, women with idiopathic generalized epilepsy may receive either substitution monotherapy or add-on therapy. There were no significant differences in effectiveness or safety between substitution monotherapy and add-on therapy in this retrospective comparative study.
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The Effect of High-Dose Vitamin D on Clinically Isolated Syndrome and MS
This study by Thouvenot et al evaluated the effectiveness of high-dose vitamin D treatment on clinically isolated syndrome and early multiple sclerosis as monotherapy and reported a reduced incidence of new disease activity compared to the control group.
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Can Anti-Amyloid Antibody Treatment Delay the Clinical Onset of Alzheimer’s Disease?
In this open-label extension of the dominantly inherited Alzheimer’s disease gantenerumab trial (DIAN-TU), long-term continuous amyloid clearance over eight or more years in asymptomatic carriers of autosomal dominant Alzheimer’s mutations showed potential to delay symptom onset and slow progression. Shorter duration or partial clearance did not yield measurable clinical benefit, suggesting that only sustained, near-complete amyloid removal may have disease-modifying effects.
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Manual Maneuvers for the Treatment of Benign Positional Vertigo
Benign positional vertigo is a challenge to treat. This clinical trial from investigators in South Korea demonstrated modest efficacy in resolving posterior canal-related vertigo with a head-shaking maneuver that is easily performed in an office setting.
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Toxic Alcohols: Mechanisms, Presentation, Evaluation, and Management
It is critical to have a high index of suspicion for toxic alcohol toxicity to make an accurate and timely diagnosis. This, in turn, facilitates expeditious treatment that may prevent morbidity and mortality in these patients.
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Preparing for Avian Influenza
Although human-to-human transmission has not been observed for avian influenza in the United States at this time, and the situation is seen only as a possibility, it is important that all emergency care providers understand the virus and its potential implications for both practice and patients.
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An Overview of Audiologic Care for the Primary Care Physician
Primary care providers play a crucial role in identifying and managing hearing and balance disorders across the lifespan. Early detection of hearing loss through screening, especially in newborns and older adults, is essential, since untreated hearing loss is associated with cognitive decline, depression, and increased healthcare costs. Collaboration with audiologists enhances patient outcomes and ensures comprehensive management of hearing and balance health throughout life.
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Gepotidacin Tablets (Blujepa)
The U.S. Food and Drug Administration has approved gepotidacin, a first-in-class antibacterial medication for the treatment of uncomplicated urinary tract infections.
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Use of Coronary Calcium Score in Familial Coronary Artery Disease
A randomized trial of computed tomography (CT) coronary artery calcium score augmented management vs. usual care of primary prevention patients at moderate risk of a coronary event and with a family history of premature coronary events has shown that, after three years of follow-up, the calcium score group had lower low-density lipoprotein cholesterol levels and smaller total plaque volumes by CT angiography.