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Small fiber neuropathy (SFN) is a relatively common disorder that affects small somatic and/or autonomic nerves. Known causes include diabetes, vitamin B12 deficiency, and Sjogren's syndrome among others, although the condition is idiopathic in most cases.
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Detailed neuropathological investigation of patients with sensory neuronopathy and polymerase γ mutations revealed evidence of posterior column atrophy in spinal cord sections and marked neuronal cell loss with severe mitochondrial biochemical abnormalities (involving respiratory chain complexes I and IV) in the dorsal root ganglia.
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New treatment for prostate cancer; avastin and breast cancer; new CMS disclosure rule; and FDA actions.
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New treatment for prostate cancer; avastin and breast cancer; new CMS disclosure rule; and FDA actions.
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Peripheral arterial disease (PAD) can cause symptomatic claudication and it can reduce quality of life.
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The management of asymptomatic patients with severe aortic stenosis (AS) is controversial. Patients meeting standard echocardiographic criteria for severe stenosis have a variety of pressure gradients and flow rates that can be divided into four categories based on normal flow vs low flow (NF vs LF) and low gradient vs high gradient (LG vs HG), where LF is defined as a stroke volume index (SVI) of < 35 mL/m2 and LG is a mean gradient < 40 mmHg.
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After acute coronary syndromes (ACS), patients remain at risk for recurrent cardiovascular events. Antiplatelet agents are the mainstay of secondary preventive strategies aimed at reducing the rate of recurrent events.
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The Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT) tested two hypotheses.
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Although electrocardiogram (ECG) left ventricular hypertrophy (LVH), especially with ST-T changes (strain pattern), is known to be of prognostic value in patients with aortic stenosis, its valve in patients who are being followed is unclear.
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