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After the voluntary withdrawal of Vioxx from the market in September 2004 following reports of increased cardiovascular events associated with the drug, there was a call from some quarters for a similar action for all selective COX-2 inhibitors (coxibs). This article reviews the current clinical knowledge regarding the coxibs and their cardiovascular effects. Recommendations for prescribing anti-inflammatory drugs in common clinical situations are provided.
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The possibility of a bird flu pandemic has health officials worldwide in a high state of alert.
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This study provides evidence of a direct relationship between periodontal microbiology and subclinical atherosclerosis. This relationship exists independent of C-reactive protein.
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In women, obstructive sleep apnea appears to be associated with idiopathic edema, even after controlling for obesity.
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A meta-analysis of 19 clinical trials found that vitamin E intake greater than the recommended 400 IU/day found a statistically significant relationship between increased dosage and all-cause mortality when compared to both controls and lower doses.
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Conjugated equine estrogen alone and CEE + MPA increased the risk of urinary incontinence among continent women and worsened the characteristics of urinary incontinence among symptomatic women after 1 year.
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Amgen has received approval to market palifermin. The drug is approved to decrease the incidence and duration of severe oral mucositis in patients with hematologic malignancies undergoing chemotherapy, with or without radiation, followed by a bone marrow transplant.
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Although all strokes are potentially debilitating, intracerebral hemorrhage is often the most disabling.
