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This cohort study prospectively compared the rate of change in the amount of coronary calcification before and after lipid-lowering therapy with the cholesterol synthesis enzyme inhibitor cerivastatin.
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There appears to be an increase in ovarian cancer with long-term estrogen-only hormone replacement therapy.
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Ambulatory blood pressure monitoring is a useful adjunct for evaluating white coat hypertension, but little is known about its effect on BP. Thus, Hermida and associates from Spain studied 538 patients with mild-to-moderate office hypertension using ABPM for 48 hours.
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There is evidence that diet could play a role in Alzheimer's disease (AD) risk. This epidemiologic study examined the risk of AD between quartiles of calorie, carbohydrate, fat, and protein intake after adjusting for confounders.
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Sleep disorders are extremely common and the primary care physician (PCP) can play an important role in their identification and management. The PCP is the first line of defense for identifying patients with sleep disorders and initiating appropriate evaluation and managing long-term treatment.
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Review of Efficacy of Ginkgo; Celebrex OK for Asthma Patients; Losartan Not Superior to Captopril; Alfa-Interferon Could Help Fight West Nile; FDA Actions
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Debate over the cardiovascular effects of COX-2 inhibitors has raged for more than a year since a special communication was published in JAMA last August suggesting an increase in cardiovascular events with rofecoxib (Vioxx). Now a large retrospect, the cohort study from the Tennessee Medicaid program seems to confirm the prothrombotic effects of rofecoxib, at least in high dose.
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