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Late in the evening you receive a page about a patient who is fighting the ventilator. You are cross-covering and do not know the patient. Your sign-out sheet says only that she is 68 years old, has severe COPD complicated by pneumonia, and has been in the ICU for the last 3 days. No specific problems are mentioned.
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Do Antidepressants Increase Risk of Suicide?; Can Viagra Improve Heart Function?; A Dramatic Increase of Clostridium difficile; FDA Actions
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Propylene glycol is used as the carrier vehicle for a number of drugs including lorazepam and diazepam. It may cause metabolic abnormalities such as anion gap metabolic (usually lactic) acidosis and hyperosmolality.
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In this study from the University of Liverpool, Duffy and associates sought to determine whether the addition of intravenous aminophylline produced clinically important improvements in the rates of symptomatic recovery or increases in pulmonary function, and whether it shortened hospital stay, in comparison with standard therapy without aminophylline, among patients with COPD who were admitted with an exacerbation.
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The first article reports the results of an industry-sponsored clinical trial comparing TDF/ABC/3TC vs EFV/ABC/3TC in treatment-naïve patients. Three hundred forty patients were randomized. Baseline characteristics, including CD4 count and HIV RNA level were similar between the arms.
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Since the fda approval of moxifloxacin in December 1991 for the treatment of community-acquired pneumonia, sinusitis, acute bacterial exacerbation of chronic bronchitis, and uncomplicated skin/skin structure infections, its indications for use has been expanded to include the treatment of complicated skin/skin structure infections and complicated intra-abdominal infections.
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This study from a single diabetic foot clinic in France involved a retrospective chart review of patients who underwent surgical percutaneous bone biopsy with culture for microbiologic diagnosis of osteomyelitis. Patients included for study were those who had not received either local or systemic antibiotics for at least 4 weeks prior to cultures being obtained.
