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In a multicenter study, critically ill patients with initial hyperlactatemia had improved outcomes (including shorter ICU stays and lower adjusted mortality) compared to control patients when they were managed for the first 8 hours with a resuscitation protocol targeted at reducing the lactate level by at least 20% every 2 hours.
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A 74-year retired veterinarian presents to the emergency department (ED) with shortness of breath. He was recently diagnosed with diffuse large-cell lymphoma with prominent abdominal lymphadenopathy and positive bone marrow and has been treated with two cycles of R-CHOP.
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Episodes of severe sepsis in older adults is associated with worsening cognition and functional status.Source: Iwashyna TJ, et al. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 2010;304:1787-94.
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This paper reports results from the resynchronization-Defibrillation for Ambulatory Heart Failure Trial (RAFT). This was a multicenter, double-blind, randomized trial testing the hypothesis that addition of resynchronization therapy (CRT) to an ICD, compared to an ICD only in patients with New York Heart Association (NYHA) class II or class III symptoms, left ventricular systolic dysfunction, and a widened QRS complex would improve survival and reduce hospitalizations.
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This paper describes the results of a study which compared two energy types, cryoenergy and radiofrequency (RF), for catheter ablation in patients with atrioventricular nodal reentrant tachycardia (AVNRT).
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Statins and liver function; dosing timing for thyroxine; rivaroxaban for VTE, DVT, and stroke; echinacea and the common cold; and FDA actions.
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Patients taking dual anti-platelet therapy (DAPT) with aspirin and clopidogrel are at higher risk of bleeding with coronary artery bypass graft surgery (CABG) than those taking aspirin alone.
