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An oral selective phosphodiesterase 4 (pde4) inhibi-tor has been approved for the treatment of patients with chronic obstructive pulmonary disease (COPD). Roflumilast is the first drug of this type to be approved for this indication. It is marketed by Forest Pharmaceuticals as Daliresp.
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In the general population, there is a linear and reversible relationship between salt intake and blood pressure (BP): more salt in begets higher BP, and salt restriction lowers BP.
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A controlled surgical trial of glutamic acid decarboxylase gene therapy, targeting the subthalamic nucleus in advanced Parkinsons's disease, demonstrated statistically significant improvement in motor symptoms off medication in those receiving gene therapy compared with controls.
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Carbamazepine has been linked with severe forms of hypersensitivity reactions. As such, genome wide approaches to identify patients-at-risk have become increasingly important.
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A composite score that combines age, motor power, and light touch perception can predict recovery of walking with great accuracy in patients with traumatic spinal cord injury.
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Seasonal flu and H1N1 vaccines are safe for patients with myasthenia gravis and should be administered.
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Decompressive craniectomy for severe diffuse traumatic brain injury and refractory intracranial hypertension (ICP) reduces ICP but increases unfavorable outcomes.
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Rotational vertebral artery syndrome (RVAS) is a rare syndrome usually caused by compression of the dominant vertebral artery in the neck with extreme head rotation to the contralateral side.
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