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Variant Creutzfeldt-Jakob disease usually presents with subtle psychiatric symptoms and there is usually a significant delay in diagnosis.
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Patients originally on interferon beta-1a in the TRANSFORMS study were re-randomized to either 0.5 or 1.25 mg of fingolimod. There was a reduction in relapse rate and MRI activity in patients that switched to fingolimod without an increase in severe adverse events.
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Biomarkers for Parkinson's disease and related neurodegenerative diseases occur frequently in patients with idiopathic REM sleep behavior disorder. These include impairment of olfactory and color discrimination, and abnormalities in cerebral blood flow.
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Entrapment neuropathies are not more common in the setting of chronic inflammatory demyelinating neuropathy and suggest a surgically treatable lesion.
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Crest failed to demonstrate any significant differ-ence in the primary endpoint (composite of stroke, myocardial infarction, or death during the 4-year follow-up period) between carotid artery stenting (CAS) and carotid endarterectomy (CEA) in patients with symptomatic or asymptomatic carotid artery stenosis.
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Two new drugs for treatment of hepatitis C; NSAIDs and myocardial infarction risk; AIM-HIGH clinical trial stopped; and FDA actions.
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Thoracic aortic dissection is notoriously difficult to diagnose. Since the presenting symptoms are protean, it is not feasible to image everyone with symptoms that could be due to dissection.
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Several studies have shown lower rates of arterial access site complications when performing cardiac catheterization via the radial artery compared to the femoral artery, but these have largely been retrospective studies or registries.
