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In postmenopausal women, constipation is associated with having major risk factors for cardiovascular disease and increased cardiovascular risk.
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This basic science paper explores the role of the tumor microenvironment in the development of tumor resistance to chemotherapy. Two distinct fatty acid molecules, endogenously produced by cancer cells in response to platinum-based chemotherapy drugs, were found to confer significant tumor chemoresistance. Remarkably, these two fatty acids also were shown to be present in several commercial fish oil products, and, of potential import to clinicians, the oral administration of small amounts of these fish oils induced tumor resistance to cisplatin in a mouse tumor model.
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Most patients with ST-elevation myocardial infarction (STEMI) present to hospitals that are not capable of percutaneous coronary intervention (PCI). Rapid transfer to PCI-capable facilities for primary PCI may result in earlier reperfusion of the infarct artery and better clinical outcomes. However, delays in transfer may diminish the mortality benefit achieved with primary PCI in STEMI.
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Anatomic definition of coronary artery lesions by invasive coronary angiography (ICA) or computed tomography coronary angiography (CCTA) has limitations.
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The most appropriate time to intervene in asymptomatic patients with chronic severe aortic regurgitation is controversial. Since brain natriuretic peptide (BNP) is released by the heart in response to increased wall stress, it has been proposed as a biomarker of the time to intervene in chronic valvular regurgitation patients.
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In this paper, Rodriguez and his colleagues from the Department of Cardiothoracic Surgery at the University of Miami report their experience with laser-assisted cardiac rhythm device lead extraction in a large group of patients.
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New recommendations for HPV vaccine; guidelines for treatment of essential tremor; updates on smoking cessation drugs; and FDA actions.
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