Internal Medicine
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Circadian Rhythms Predict Small Vessel Ischemic Disease
The presence of white matter infarcts and cerebral microbleeds is associated with disruption of sleep but not total sleep time.
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Pattern of Atrial Fibrillation Is Associated with Outcomes After Stroke
In a Japanese stroke registry, permanent as opposed to paroxysmal atrial fibrillation was associated with higher in-hospital mortality after stroke.
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Blood Pressure Lowering After Acute Stroke: Can It Kill You?
Patients with chronically elevated blood pressure are at increased risk of all-cause and cardiovascular death, with a particularly increased risk of ischemic and hemorrhagic stroke. Treatment to lower systolic BP decreases stroke risk, without an apparent lower threshold down to 120 mmHg. However, lowered SBP (≤ 120 mmHg) in the 5 years after a stroke may be associated with increased mortality. Lower SBP over a shorter period of time after a stroke in chronically hypertensive patients could potentially increase mortality as well.
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Incidental Cerebral Microbleeds and Cerebral Blood Flow in Elderly Individuals
Cerebral microbleeds in non-demented elderly people are associated with a global reduction in cerebral blood flow and a high prevalence of beta-amyloid deposition in the brain.
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Idarucizumab: A Promising New Drug that Reverses the Anticoagulant Effects of Dabigatran
A recent study found that idarucizumab rapidly reverses the effects of dabigatran and is likely to have important clinical benefits for patients with intracerebral hemorrhage and other disease processes in which reversal of anticoagulation is important.
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Diverticulitis: Evaluation and Management
Diverticulitis is a result of acute inflammation of colonic diverticulum. Acute diverticulitis is placing an increasing burden on health care resources as the incidence, prevalence, and hospital admission rate is rapidly increasing. Its timely diagnosis and treatment are essential to help improve outcomes for patients. The ability to recognize complicated versus uncomplicated diverticulitis can aid in expedited care and resource allocation to prevent repeat radiation exposure through radiological imaging of these patients who present with uncomplicated diverticulitis.
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Using Critical Care Ultrasonography to Diagnose the Etiology of Acute Respiratory Failure
Thoracic ultrasound and limited echocardiography may be useful to help differentiate the causes of acute hypoxic respiratory failure in the ICU.
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Optimal Duration of Anticoagulation for Unprovoked Pulmonary Embolism
Treatment for 24 months with oral anticoagulation for unprovoked, first-time pulmonary embolism was superior to treatment for 6 months only.
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The Complex Intersection of Critical and Palliative Care
Ventilator withdrawal with expected death is now considered an ethically and morally acceptable practice. Here's what you need to know.
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Clinical Briefs
In this section: Reconsidering the value of oral nutritional supplementation in patients admitted for COPD; recognizing a relationship between asthma and obesity; and weighing the benefits of sound stimulation in Alzheimer's patients.