Internal Medicine
RSSArticles
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Rivaroxaban in the Real World
A large Phase IV registry study shows that rivaroxaban is associated with a very low incidence of major bleeding, death, or stroke. Also, adherence to therapy was much higher than observed in other studies with vitamin K antagonists.
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New Analysis of COGENT Data Supports Proton Pump Inhibitor Benefit
It shows comparable risks of gastrointestinal and cardiovascular events between low- and high-dose aspirin.
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Acetazolamide in Mechanically Ventilated Patients with COPD: Is There a Benefit?
Compared to placebo, the use of acetazolamide in mechanically ventilated patients with COPD does not significantly reduce the duration of mechanical ventilation.
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Communication Facilitators Potentially Can Improve Care for the Sickest ICU Patients
Highly trained communication facilitators who counseled families and met with physicians and nurses were shown to decrease symptoms of depression in family members at six months and decreased ICU length of stay without affecting mortality.
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Delaying Intubation in Severe Alcohol Withdrawal
Delaying intubation until aspiration or cardiopulmonary decompensation did not affect mortality but increased the incidence of pneumonia and length of stay.
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Patients Rarely Sleep in the ICU
Understanding the mechanisms of sleep deprivation in the ICU may help clinicians modify some of these factors to promote better quality sleep.
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Clinical Briefs
In this section: watching carefully for suicide risk; tackling chronic cough; and a new treatment for Peyronie's disease.
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Reslizumab Injection (Cinqair)
Reslizumab is indicated for add-on maintenance treatment of adult patients with severe asthma with eosinophilic phenotype.
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Longer Course Therapy for Lyme Disease Is Not Beneficial
A randomized, placebo-controlled clinical trial from the Netherlands found that longer-term antibiotic therapy for Lyme disease did not improve health-related quality of life compared to a standard course of treatment.
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Predicting Seizure Recurrence with Routine EEG After First Unprovoked Seizure
Using positive likelihood ratios, an adult and child with epileptiform discharges on electroencephalography were estimated to have a 77% and 66% probability, respectively, of recurrent seizures.