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Colistin vs. Polymyxin B

Based on their kinetics and toxicity profiles, polymyxin B may be the preferred agent for treatment of systemic infections, while colistin is preferred for infections limited to the urinary tract.

Severe Infection Due to Human Adenovirus B7

Oregon health authorities identified 198 patients from October 2013 until July 2014 with respiratory symptoms and a human adenovirus (HAdV)-positive respiratory specimen. Of the 136 patients (69%) who were hospitalized, 31% were admitted to ICU, 18% required mechanical ventilation, and five patients died. Patients with HAdV-B7 were more likely to be adults and to have longer hospital stays.

Refining the Evaluation and Management of Neonatal Herpes Infection

Neonatal herpes infection usually presents with seizure, vesicular rash, or critical illness. The subset of infected patients without those signs were younger than two weeks of age and/or had cerebrospinal fluid pleocytosis.

The Zoster Vaccine Rapidly Loses Effectiveness in Adults Over 60

An observational study from Kaiser Permanente Southern California showed that while the shingles vaccine reduces the risk of herpes zoster, there is a major decline in effectiveness over just eight years in older adults.

It Was Inevitable: mcr-1 in the United States

Plasmid-mediated resistance to colistin has been detected in the United States for the first time, raising concern about its potential for rapid dissemination.

Integrative Treatment for Restless Legs Syndrome: What Does the Evidence Say?

Medical evidence supports the use of physical activity and iron supplementation (for those with low serum ferritin) in patients with restless legs syndrome.

Integrative Approaches to Caring for Children with Autism

Selected treatments for autism spectrum disorder are reviewed and placed into one of four categories (ranging from recommend to avoid) with a goal of creating a practical blueprint for the medical practitioner.

Improving Blood Pressure Through Enhanced Sleep

The use of a benzodiazepine hypnotic among hypertensive patients was associated with improvements in both sleep scores and blood pressure.

Combination of Simvastatin Plus Vitamin D Offers New Hope for Migraine Prevention

A well-conducted, randomized, placebo-controlled trial has shown that the combination of simvastatin (20 mg twice daily) plus vitamin D3 (1,000 international units twice daily) is effective in the prevention of headaches in adults with episodic migraine.

FDA Nutrition Facts Label Changes

The FDA recently announced changes to the nutrition facts panel required as a label on all foods.